Identification of a novel inhibitor of mitogen-activated protein kinase kinaseU0126 protects cells against oxidative stress independent of its function as a MEK inhibitor.U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female ratsMEK1/2 inhibitor U0126 but not endothelin receptor antagonist clazosentan reduces upregulation of cerebrovascular contractile receptors and delayed cerebral ischemia, and improves outcome after subarachnoid hemorrhage in rats.Lipopolysaccharide induces cytokine production and decreases extravillous trophoblast invasion through a mitogen-activated protein kinase-mediated pathway: possible mechanisms of first trimester placental dysfunctionSensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6).Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via extracellular signal-regulated kinase/mitogen-activated protein kinase in pigletsInhibition of tumor growth by U0126 is associated with induction of interferon-γ production.Cytoplasmic estrogen receptor β as a potential marker in human non-small cell lung carcinoma.The novel dual PI3K/mTOR inhibitor GDC-0941 synergizes with the MEK inhibitor U0126 in non-small cell lung cancer cells.NO donor and MEK inhibitor synergistically inhibit proliferation and invasion of cancer cells.Diallyl disulfide induces MUC5B expression via ERK2 in human airway epithelial cells.Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines.MEK/Erk-based negative feedback mechanism involved in control of Steel Factor-triggered production of Krüppel-like factor 2 in mast cells.Suppression of the cough reflex by inhibition of ERK1/2 activation in the caudal nucleus tractus solitarii of the rabbit.Involvement of the extracellular signal-regulated kinase 1/2 signaling pathway in amylin's eating inhibitory effect.dl-3n-Butylphthalide promotes angiogenesis via the extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase/Akt-endothelial nitric oxide synthase signaling pathways.Curcumin protects against regional myocardial ischemia/reperfusion injury through activation of RISK/GSK-3β and inhibition of p38 MAPK and JNK.[INHIBITORS OF MAP-KINASE PATHWAY U0126 AND PD98059 DIFFERENTLY AFFECT ORGANIZATION OF TUBULIN CYTOSKELETON AFTER STIMULATION OF EGF RECEPTOR ENDOCYTOSIS].Production of Japanese Black calves by the transfer of embryos developed from in vitro-fertilized oocytes derived by ovum pick up and matured in culture with the mitogen-activated protein kinase kinase inhibitor U0126U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway
P921
Q29616448-EE5C391C-1B6A-4F11-9BD8-3AD6C91D4031Q35006087-F607FC6B-14BF-4FC9-8707-0A3AAF7BED79Q35143502-0E4266BC-48AA-423C-B687-B79374161512Q35591265-E41DAF27-8D95-4AF0-BE26-B9E1AC317E66Q35620766-84B650B7-1BD8-4443-A12E-294243AEB57BQ35742243-3E3CAFBF-9DAA-4F51-87E6-A008852E5E81Q35799306-5F1E81CB-A993-4FB1-9DEA-D10F93792507Q38982765-818B8E26-81E2-4402-B54E-C3729D30FB20Q39400232-F32CE1CE-DAA3-4075-BCFB-265BE9C86161Q39439982-08E073C2-DCA4-4732-A26D-6A326AFAEB7AQ39453300-3907C900-7F8E-494C-9463-8E42562C9DFFQ39535206-0B08A5E5-1E64-4835-A084-8C8E20E67D25Q42721055-760B8747-33CE-42F3-B2D7-C2CC9D0D1E7EQ46585206-1721FFAE-A1B9-4E7B-A3F9-8F5A75A8B52BQ48678784-9DC3C3C9-C2CC-45E8-9FAA-3E7F658F0E14Q51364602-6924D3C3-5F1A-4C6E-9403-F62593E78571Q53675217-434A8181-68AD-4D7C-A395-9B1E3147C079Q54524973-E4CACD4E-6C02-425D-9001-D40F7B05E243Q55043510-A003C378-F748-4011-A633-A3F41F766640Q64226691-31E09C70-02B5-47F2-885A-CF64943225E5Q85897006-882AAC8F-DBAA-490C-AB22-02A5E3ADA8C5
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
U0126
@de
U0126
@en
U0126
@fa
U0126
@ja
type
label
U0126
@de
U0126
@en
U0126
@fa
U0126
@ja
altLabel
(2Z,3Z)-Bis{amino[(2-aminophenyl)sulfanyl]methylen}succinonitril
@de
(2Z,3Z)-bis[amino(sulfanyl)methylidene]butanedinitrile
@en
prefLabel
U0126
@de
U0126
@en
U0126
@fa
U0126
@ja
P592
P662
P683
P2017
Nc1ccccc1S\C(N)=C(C#N)\C(C#N)=C(/N)Sc1ccccc1N
P231
109511-58-2
P234
1S/C18H16N6S2/c19-9-11(17(23)2 ...... 2/h1-8H,21-24H2/b17-11+,18-12+
P235
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
P274
C₁₈H₁₆N₆S₂
P3117
DTXSID4040470
P592
CHEMBL34704
P652
8027P94HLL