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Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitorsBenzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message.CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339.Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4.Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia.Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model.Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells.Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System.Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.The role of pH in the glucuronidation of raloxifene, mycophenolic acid and ezetimibe.Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole.Insensitivity to pain upon adult-onset deletion of Na1.7 or its blockade with selective inhibitorsThe role of P-glycoprotein in the bioactivation of raloxifeneUnremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouseComprehensive Evaluation of Bile Acid Homeostasis in Human Hepatocyte Co-Culture in the Presence of Troglitazone, Pioglitazone, and Acetylsalicylic AcidOptimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple MyelomaDiscovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy VolunteersStructure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic PainInvestigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic RatsUnequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Jae H Chang
@en
Jae H Chang
@nl
type
label
Jae H Chang
@en
Jae H Chang
@nl
prefLabel
Jae H Chang
@en
Jae H Chang
@nl
P31
P496
0000-0003-3457-7695