about
Seizure control by ketogenic diet-associated medium chain fatty acidsNaringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.A novel human receptor involved in bitter tastant detection identified using Dictyostelium discoideum.Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.Zizimin and Dock guanine nucleotide exchange factors in cell function and disease.Non-Catalytic Roles of Presenilin Throughout Evolution.Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro modelAn ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms.New experimental therapies for status epilepticus in preclinical development.Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid.Tipping the scales: Lessons from simple model systems on inositol imbalance in neurological disorders.The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles.Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum.Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-β oligomers released from 7PA2 cells.Employing Dictyostelium as an Advantageous 3Rs Model for Pharmacogenetic Research.Bitter tastant responses in the amoeba Dictyostelium correlate with rat and human taste assays.An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling.Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid inA new mechanism for cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy modelsGamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Robin S B Williams
@en
Robin S B Williams
@nl
type
label
Robin S B Williams
@en
Robin S B Williams
@nl
prefLabel
Robin S B Williams
@en
Robin S B Williams
@nl
P31
P496
0000-0002-9826-6020