about
The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exitDefective sister chromatid cohesion is synthetically lethal with impaired APC/C function.MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1.Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase.The spindle checkpoint, APC/C(Cdc20), and APC/C(Cdh1) play distinct roles in connecting mitosis to S phase.Stable government of mitosis by Greatwall: the emperor's best servant.Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selectionEffective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repairChemopreventive targeted treatment of head and neck precancer by Wee1 inhibitionCharacterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass[CRISPR/Cas: technique to repair DNA errors: is a clinical breakthrough near?]Keeping ribosomal DNA intact: a repeating challengePHF6 promotes non-homologous end joining and G2 checkpoint recoveryNo evidence for increased prevalence of colorectal carcinoma in 399 Dutch patients with Birt-Hogg-Dubé syndromeTargeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Rob M F Wolthuis
@en
Rob M F Wolthuis
@nl
type
label
Rob M F Wolthuis
@en
Rob M F Wolthuis
@nl
prefLabel
Rob M F Wolthuis
@en
Rob M F Wolthuis
@nl
P31
P496
0000-0002-3109-1588