about
Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeastRobust heat shock induces eIF2alpha-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae.Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast.Mmi1, the yeast homologue of mammalian TCTP, associates with stress granules in heat-shocked cells and modulates proteasome activitySmall heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding.A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins.Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stressCellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
P50
Q27937355-57A42028-9A9A-4788-910E-C478F2A3560DQ27940310-BE050F88-8F22-441E-9F8D-8E20396A5778Q29346875-349D9D65-631D-4A8C-8955-7EF14263AA94Q35035626-729751DC-1791-47D0-94F7-85212D792A2EQ37479435-A2284EE7-66B1-468D-AB26-76DB30B94E92Q48181646-2C497353-3BF3-4B98-9F60-A4E0E1C4FE01Q57083958-066A8116-ABFC-473F-B010-49D190F7BF85Q90929529-16275BBD-5F3A-4970-970A-42E949C18970
P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Tomás Grousl
@en
Tomás Grousl
@nl
type
label
Tomás Grousl
@en
Tomás Grousl
@nl
prefLabel
Tomás Grousl
@en
Tomás Grousl
@nl
P31
P496
0000-0002-6996-1323