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Engineering the gut for insulin replacement to treat diabetesMaintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiologyStatistical approaches and software for clustering islet cell functional heterogeneity.Cardiac ryanodine receptors control heart rate and rhythmicity in adult miceClonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineagesThe role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapyGlucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survivalGlucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion.A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control.The role of leptin in glucose homeostasis.A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression.Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemiaHyperinsulinemia drives diet-induced obesity independently of brain insulin production.Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance.In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ß-cell proliferation and improves pathology in the db/db mouse model of diabetes.Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination.Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells.GIP or not GIP? That is the question.Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.Pleiotropic effects of GIP on islet function involve osteopontin.Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs.Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling.The Role of ARX in Human Pancreatic Endocrine Specification.Characterization of Antibodies to Products of Proinsulin Processing Using Immunofluorescence Staining of Pancreas in Multiple Species.Harnessing the gut to treat diabetes.Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice.Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed ratsLink between GIP and osteopontin in adipose tissue and insulin resistanceLeptin administration enhances islet transplant performance in diabetic mice.Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lep(ob/ob) mice.Clinical application of glucagon-like Peptide 1 receptor agonists for the treatment of type 2 diabetes mellitus.Mining incretin hormone pathways for novel therapies.Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects.Profiling of circulating microRNAs in children with recent onset of type 1 diabetes.Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob miceTreatment of diabetes with glucagon-like peptide-1 gene therapy.K-cells and glucose-dependent insulinotropic polypeptide in health and disease.Restoring insulin production for type 1 diabetes.
P50
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P50
name
Timothy J Kieffer
@en
type
label
Timothy J Kieffer
@en
prefLabel
Timothy J Kieffer
@en