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In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations.Simultaneous detection of multiple DNA adducts in human lung samples by isotope-dilution UPLC-MS/MSGlucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice.Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation.A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells.Optimized enzymatic hydrolysis of DNA for LC-MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol.Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels.Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium.The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens.Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells.Pathological manifestations of Farber disease in a new mouse modelVentilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in miceVitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor in colon cancer cellsFibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptakeMethod to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometryDown-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxinsVitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cellsCharacterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitroAcid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe diseaseAntidepressants act by inducing autophagy controlled by sphingomyelin-ceramideMonitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass SpectrometryUse of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitroRole of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol HomeostasisSynthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug deliveryInterleukin-22 protects intestinal stem cells against genotoxic stressIntestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven ColitisThe Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain InjuryCore-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skinAcid sphingomyelinase - a regulator of canonical transient receptor potential channel 6 (TRPC6) activityAcid Sphingomyelinase Deficiency Ameliorates Farber DiseaseQualifying X-ray and Stimulated Raman Spectromicroscopy for Mapping Cutaneous Drug PenetrationClinical Development of Sphingosine as Anti-Bacterial Drug: Inhalation of Sphingosine in Mini Pigs has no Adverse Side EffectsDermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based NanogelsSphingosine-coating of plastic surfaces prevents ventilator-associated pneumoniaMeasles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistenceImmunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation
P50
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P50
description
investigador
@es
researcher
@en
name
Fabian Schumacher
@en
type
label
Fabian Schumacher
@en
prefLabel
Fabian Schumacher
@en
P31
P496
0000-0001-8703-3275