about
Insights into the key roles of proteoglycans in breast cancer biology and translational medicineA modified protocol for isolation and purity evaluation of a staphylococcal acidic polysaccharide by chromatography and capillary electrophoresis.IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM moleculesCross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of proteoglycans.Syndecans as modulators and potential pharmacological targets in cancer progression.The role of heparins and nano-heparins as therapeutic tool in breast cancer.Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules.Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma.Syndecans - key regulators of cell signaling and biological functions.Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells.Evaluation of the coordinated actions of estrogen receptors with epidermal growth factor receptor and insulin-like growth factor receptor in the expression of cell surface heparan sulfate proteoglycans and cell motility in breast cancer cells.Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticalsFACE analysis as a fast and reliable methodology to monitor the sulfation and total amount of chondroitin sulfate in biological samples of clinical importance
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Nikos Afratis
@en
Nikos Afratis
@nl
type
label
Nikos Afratis
@en
Nikos Afratis
@nl
prefLabel
Nikos Afratis
@en
Nikos Afratis
@nl
P31
P496
0000-0002-3962-2451