about
Conformational activation of ADAMTS13.A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von Willebrand factor.The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis.Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke.N-linked glycan stabilization of the VWF A2 domainFactor V has an anticoagulant cofactor activity that targets the early phase of coagulation.Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity.A common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct.Biphasic activation of complement and fibrinolysis during the human nasal allergic response.ADAMTS-13 and von Willebrand factor: a dynamic duo.The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertensionEnhanced activity of an ADAMTS-13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischemic strokeDefective fibrin deposition and thrombus stability in Bambi-/- mice are mediated by elevated anticoagulant functionExosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and ProteolysisThe roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complexPartial rescue of naturally occurring active site factor X variants through decreased inhibition by tissue factor pathway inhibitor and antithrombin
P50
Q33419359-87CE6D72-01CC-4388-BC5F-53A61999BB6AQ33567628-A57928B8-7398-4363-8051-8B9F3223AE84Q35197446-5CAB2600-D44F-4329-BE7A-A9082A612164Q35591917-6FEAFB10-DAD7-4C97-9D41-F4DECB45B56CQ39773996-1369005C-2BB4-4A7A-AA0F-5AB8C0E108A4Q41936652-491C137D-E25D-4851-B0FB-2CD50FF11F23Q41946735-D26CDCE7-CA97-4D5B-9B0A-EE281DE69981Q47104681-E07F960F-FAAC-40E2-AF41-159597891A60Q50086913-8466B399-93DB-47E6-B171-3EEA7EE9B6F7Q50135856-63033ED2-149B-464F-B0E1-330F24729FFAQ63916372-DB488BC6-DB35-4FC8-895E-7E7AF3E60D4AQ91177062-43751424-CAAB-417D-8FAF-6B28A98DED5BQ92218948-6060FB59-FD1A-40E7-A42A-1180DB22C84AQ92266460-64827253-75E4-4F6E-A3C3-379751496DFEQ92304190-5176378C-1E8E-4FFE-8C8B-B1867433C95DQ92986959-51C501A9-65D3-40F0-811C-36238A71DB6C
P50
description
investigador
@es
researcher
@en
name
David A Lane
@en
type
label
David A Lane
@en
prefLabel
David A Lane
@en
P31
P496
0000-0003-4283-3695