about
Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells.Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade.Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance.T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses.Normalizing the environment recapitulates adult human immune traits in laboratory mice.Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells.Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organsPreexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting.Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.T-cell invigoration to tumour burden ratio associated with anti-PD-1 response.Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death.NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade.Oncolytic Viruses-Natural and Genetically Engineered Cancer Immunotherapies.High-dose IL-2 induces rapid albumin uptake by endothelial cells through Src-dependent caveolae-mediated endocytosis.Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory.A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma.T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells.Integrated stress response and immune cell infiltration in an ibrutinib-refractory mantle cell lymphoma patient following ONC201 treatmentIL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor DevelopmentCRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancerUse of a Blast Dominance-Hematogone Index for the Flow Cytometric Evaluation of Myelodysplastic Syndrome (MDS)Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancerCD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responsesPlateletpheresis-associated lymphopenia in frequent platelet donors
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description
investigador
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researcher
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name
Jason M Schenkel
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type
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Jason M Schenkel
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prefLabel
Jason M Schenkel
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P108
P31
P496
0000-0003-4641-6872