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Insights into antifolate resistance from malarial DHFR-TS structuresExploiting Structural Analysis, in Silico Screening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum MalariaPreclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug CandidateTrypanosomal dihydrofolate reductase reveals natural antifolate resistanceMalarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetCombined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to CycloguanilCytochrome c and c1 heme lyases are essential in Plasmodium bergheiTarget guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparumA genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolatesInducible knockdown of Plasmodium gene expression using the glmS ribozymeMolecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteinsCharacterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5' cap statusOrigin of robustness in generating drug-resistant malaria parasitesSynthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.Comparative proteomic profiles and the potential markers between Burkholderia pseudomallei and Burkholderia thailandensis.Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library.Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei modelAntimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening.Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridineEstimating mRNA lengths from Plasmodium falciparum genes by Virtual Northern RNA-seq analysis.Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins.Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum.Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study.Inhibition of Glutathione Biosynthesis Sensitizes Plasmodium berghei to Antifolates.Folate metabolism as a source of molecular targets for antimalarials.Stepwise acquisition of pyrimethamine resistance in the malaria parasiteCurrent treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review.2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae).Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling.Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum.Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050.GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile.Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding.
P50
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P50
name
Sumalee Kamchonwongpaisan
@en
type
label
Sumalee Kamchonwongpaisan
@en
prefLabel
Sumalee Kamchonwongpaisan
@en