about
Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation
P50
description
researcher
@en
wetenschapper
@nl
name
Harald Steiner
@en
Harald Steiner
@nl
type
label
Harald Steiner
@en
Harald Steiner
@nl
prefLabel
Harald Steiner
@en
Harald Steiner
@nl
P31
P496
0000-0003-3935-0318