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Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replicationVersatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein.Design and Validation of Novel Chikungunya Virus Protease Inhibitors.Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template.Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.Correction for Utt et al., Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2.Correction for Thaa et al., Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.A Chikungunya virus trans-replicase system reveals the importance of delayed non-structural polyprotein processing for efficient replication complex formation in mosquito cells.Identification of Alphavirus Inhibitors by Using Virus-Based Assays and a Chikungunya Replicon Cell LineDecreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAsADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replicationMutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.Structural insights into RNA recognition by the Chikungunya virus nsP2 helicaseVCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other AlphavirusesSensitivity of Alphaviruses to G3BP Deletion Correlates with Efficiency of Replicase Polyprotein ProcessingDesign and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription
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Age Utt
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Age Utt
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Age Utt
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Age Utt
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Age Utt
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