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Q34362524-71CBD4BB-52F0-4B36-82FC-F85AD8F1D016
Q34362524-71CBD4BB-52F0-4B36-82FC-F85AD8F1D016
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http://www.wikidata.org/entity/statement/Q34362524-71CBD4BB-52F0-4B36-82FC-F85AD8F1D016
VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.
P2860
Q34362524-71CBD4BB-52F0-4B36-82FC-F85AD8F1D016
BestRank
Statement
http://www.wikidata.org/entity/statement/Q34362524-71CBD4BB-52F0-4B36-82FC-F85AD8F1D016
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wasDerivedFrom
c707c9cf8b48600a7807059f897e6556f704154f
P2860
Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function.