History of at least two moderate or severe exacerbations that required change in treatment (antibiotics, systemic steroids, hospitalization) in the last 18 months prior to date of screening , with at least one of these occurring within the last 12 months prior to screening. [clinicaltrials_resource:120a305da4a29ee5741b4c0182cabaa6]

History of at least two moderate or severe exacerbations that required change in treatment (antibiotics, systemic steroids, hospitalization) in the last 18 months prior to date of screening , with at least one of these occurring within the last 12 months prior to screening. [clinicaltrials_resource:120a305da4a29ee5741b4c0182cabaa6]