Part A: Skin inflammatory response measurement as induration by the ball point pen technique Over a four day period after challenge [clinicaltrials_resource:2698feb0b6180b440839b500fc6e2451]

The induration of wheals (defined as elevation and induration that are palpable in the skin) that develop as a result of intradermal immunisation with KLH or PPD will be measured in the vertical and horizontal plane using the ball point pen technique. The diameter of the induration will be measured by rolling a medium ball point pen from 10 to 20 millimetre (mm) outside the edge of the induration and toward the centre with just enough pressure to indent the skin slightly.

Part A: Skin inflammatory response measurement as induration by the ball point pen technique Over a four day period after challenge [clinicaltrials_resource:2698feb0b6180b440839b500fc6e2451]

The induration of wheals (defined as elevation and induration that are palpable in the skin) that develop as a result of intradermal immunisation with KLH or PPD will be measured in the vertical and horizontal plane using the ball point pen technique. The diameter of the induration will be measured by rolling a medium ball point pen from 10 to 20 millimetre (mm) outside the edge of the induration and toward the centre with just enough pressure to indent the skin slightly.