Reduction in Migraine Frequency (amitriptyline and topiramate) 4 week baseline period to last 4 weeks of the 24-week trial [clinicaltrials_resource:2c7f7d571c539c46f29dd160750ee284]

To test if amitriptyline and topiramate are superior to placebo in reducing migraine frequency, as defined by the percentage of subjects with a 50% reduction in the number of migraine days per month, in children and adolescents ages 8-17.

Reduction in Migraine Frequency (amitriptyline and topiramate) 4 week baseline period to last 4 weeks of the 24-week trial [clinicaltrials_resource:2c7f7d571c539c46f29dd160750ee284]

To test if amitriptyline and topiramate are superior to placebo in reducing migraine frequency, as defined by the percentage of subjects with a 50% reduction in the number of migraine days per month, in children and adolescents ages 8-17.