Number of subjects experiencing dose limiting toxicity (DLT) Up to Day 28 of Cycle 1 [clinicaltrials_resource:33ff801e4e6824920d8585e208d338a3]

TH-302 will be administered at a dose ranging from 170-340 milligram per square meter (mg/m^2) as intravenous infusion over 30 minutes on Days 1, 8 and 15 of every 28-day cycle until evidence of progressive disease, intolerable toxicity or subject withdrawal.

Number of subjects experiencing dose limiting toxicity (DLT) Up to Day 28 of Cycle 1 [clinicaltrials_resource:33ff801e4e6824920d8585e208d338a3]

TH-302 will be administered at a dose ranging from 170-340 milligram per square meter (mg/m^2) as intravenous infusion over 30 minutes on Days 1, 8 and 15 of every 28-day cycle until evidence of progressive disease, intolerable toxicity or subject withdrawal.