Clinical response (CR, CRi, PR) Up to 3 years [clinicaltrials_resource:414472ae4d1c300768c3bd663d0f6804]
Relevant individual PK parameters will be estimated using non-compartmental PK methods. PK parameters will be compared when administered alone or in combination by a paired student's t-test. Comparison of PK parameters among dose levels will be performed using non-parametric statistical methods for K-independent samples. Associations between exposure parameters (Cmax and AUC) and pharmacodynamic endpoints (cellular PAR levels, mutation and/or altered expression of selected DNA repair genes) will be assessed using the appropriate non-parametric statistical tests.
clinicaltrials_vocabulary:primary outcome [clinicaltrials_vocabulary:clinicaltrials_vocabulary:primary-outcome]
Clinical response (CR, CRi, PR) Up to 3 years [clinicaltrials_resource:414472ae4d1c300768c3bd663d0f6804]
Relevant individual PK parameters will be estimated using non-compartmental PK methods. PK parameters will be compared when administered alone or in combination by a paired student's t-test. Comparison of PK parameters among dose levels will be performed using non-parametric statistical methods for K-independent samples. Associations between exposure parameters (Cmax and AUC) and pharmacodynamic endpoints (cellular PAR levels, mutation and/or altered expression of selected DNA repair genes) will be assessed using the appropriate non-parametric statistical tests.
Bio2RDF identifier
414472ae4d1c300768c3bd663d0f6804
Bio2RDF namespace
clinicaltrials_resource
Bio2RDF uri
http://bio2rdf.org/clinicaltrials_resource:414472ae4d1c300768c3bd663d0f6804
measure [clinicaltrials_vocabulary:measure]
Clinical response (CR, CRi, PR)
time frame [clinicaltrials_vocabulary:time-frame]
Up to 3 years
description
Relevant individual PK paramet ...... -parametric statistical tests.
identifier
clinicaltrials_resource:414472ae4d1c300768c3bd663d0f6804
title
Clinical response (CR, CRi, PR) Up to 3 years
@en
type
label
Clinical response (CR, CRi, PR ...... 472ae4d1c300768c3bd663d0f6804]
@en