MTD of ixabepilone defined as the first dosage tier below the MAD in which =< 1/6 patients experiences a DLT 28 days [clinicaltrials_resource:4b5ecf03b9856401c8fc87ccbb80b08f]

Patients receive BMS-247550 IV over 1 hour on days 1, 8, and 15 followed by carboplatin IV over 1 hour on day 1. Treatment repeats every 28 days for at least 2 courses in the absence of disease progression or unacceptable toxicity. Patients with a CR receive 2 additional courses after achieving CR or up to a total of 6 courses

MTD of ixabepilone defined as the first dosage tier below the MAD in which =< 1/6 patients experiences a DLT 28 days [clinicaltrials_resource:4b5ecf03b9856401c8fc87ccbb80b08f]

Patients receive BMS-247550 IV over 1 hour on days 1, 8, and 15 followed by carboplatin IV over 1 hour on day 1. Treatment repeats every 28 days for at least 2 courses in the absence of disease progression or unacceptable toxicity. Patients with a CR receive 2 additional courses after achieving CR or up to a total of 6 courses