Response rate at 6 weeks after start of therapy (after 2 initial courses) [clinicaltrials_resource:4e772fdb8a882f21887ef997a4defd9c]

Response rate will be defined as the proportion of patients who achieved complete response or partial response (CR+PR) using the World Health Organization (WHO) criteria evaluated after two initial courses of temsirolimus, temozolomide and irinotecan in previously untreated patients with high risk ESFT. Participants who are treated in Group B with DSRCT or those who do not receive window therapy will not be included in this analysis.

Response rate at 6 weeks after start of therapy (after 2 initial courses) [clinicaltrials_resource:4e772fdb8a882f21887ef997a4defd9c]

Response rate will be defined as the proportion of patients who achieved complete response or partial response (CR+PR) using the World Health Organization (WHO) criteria evaluated after two initial courses of temsirolimus, temozolomide and irinotecan in previously untreated patients with high risk ESFT. Participants who are treated in Group B with DSRCT or those who do not receive window therapy will not be included in this analysis.