17-hydroxyprogesterone responses to hCG with and without FSH in PCOS women and normal controls up to 2 years [clinicaltrials_resource:55b502f8f9619c1a218b44ac584d6f20]
Each subject will undergo pelvic 3D ultrasound followed by an iv recombinant human chorionic gonadotropin (r-hCG) stimulation test. One month later the r-hCG test will be repeated 24 hr after an injection of recombinant human follicle stimulating hormone (FSH).
After 1 month, subjects will receive a 7 hr dose-response infusion of adrenocorticotropin (ACTH) with blood sampling. Dexamethasone will be given prior to ACTH.
After 1 month, subject will receive r-hCG as described above followed the next day by an oral glucose tolerance test (OGTT). Subsequently, subjects will take Diazoxide 3 times a day for 2 weeks. At weekly intervals (2 weeks), the r-hCG stimulation test will be repeated followed the next day by an OGTT as described above.
clinicaltrials_vocabulary:secondary outcome [clinicaltrials_vocabulary:clinicaltrials_vocabulary:secondary-outcome]
17-hydroxyprogesterone responses to hCG with and without FSH in PCOS women and normal controls up to 2 years [clinicaltrials_resource:55b502f8f9619c1a218b44ac584d6f20]
Each subject will undergo pelvic 3D ultrasound followed by an iv recombinant human chorionic gonadotropin (r-hCG) stimulation test. One month later the r-hCG test will be repeated 24 hr after an injection of recombinant human follicle stimulating hormone (FSH).
After 1 month, subjects will receive a 7 hr dose-response infusion of adrenocorticotropin (ACTH) with blood sampling. Dexamethasone will be given prior to ACTH.
After 1 month, subject will receive r-hCG as described above followed the next day by an oral glucose tolerance test (OGTT). Subsequently, subjects will take Diazoxide 3 times a day for 2 weeks. At weekly intervals (2 weeks), the r-hCG stimulation test will be repeated followed the next day by an OGTT as described above.
Bio2RDF identifier
55b502f8f9619c1a218b44ac584d6f20
Bio2RDF namespace
clinicaltrials_resource
Bio2RDF uri
http://bio2rdf.org/clinicaltrials_resource:55b502f8f9619c1a218b44ac584d6f20
measure [clinicaltrials_vocabulary:measure]
17-hydroxyprogesterone respons ...... PCOS women and normal controls
time frame [clinicaltrials_vocabulary:time-frame]
up to 2 years
description
Each subject will undergo pelv ...... by an OGTT as described above.
identifier
clinicaltrials_resource:55b502f8f9619c1a218b44ac584d6f20
title
17-hydroxyprogesterone respons ...... normal controls up to 2 years
@en
type
label
17-hydroxyprogesterone respons ...... 502f8f9619c1a218b44ac584d6f20]
@en