Recommended dose of PDX given in combination with a fixed dose of 5-FU administered as a 48-hour infusion given every other week During the initial course [clinicaltrials_resource:a8ace48d8250cb8da2bed760af733bdf]

Maximum tolerated dose will have been exceeded when 2 patients entered at a given dose level experience specified dose-limiting toxicities in the initial cycle.

Recommended dose of PDX given in combination with a fixed dose of 5-FU administered as a 48-hour infusion given every other week During the initial course [clinicaltrials_resource:a8ace48d8250cb8da2bed760af733bdf]

Maximum tolerated dose will have been exceeded when 2 patients entered at a given dose level experience specified dose-limiting toxicities in the initial cycle.