MTD of palbociclib isethionate defined as the highest dose level at which six patients have been treated with at most one patient experiencing a dose limiting toxicity and the next higher dose level has been determined to be too toxic 4 weeks [clinicaltrials_resource:ae6accf221a225b1e2e51153edf0e99e]

Will be graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.

MTD of palbociclib isethionate defined as the highest dose level at which six patients have been treated with at most one patient experiencing a dose limiting toxicity and the next higher dose level has been determined to be too toxic 4 weeks [clinicaltrials_resource:ae6accf221a225b1e2e51153edf0e99e]

Will be graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.