The primary endpoint for assessment of the live attenuated vaccine take will be the AUC of the live vaccine virus shedding determined by 50% tissue culture infectious dose (TCID ) on MDCK cells at 33 degrees C nasal swabs obtained at days 2 post vaccination [clinicaltrials_resource:c0fabea4154e7b3de2267ddd2014dbee]

0.2 ml dose of live monovalent vaccine delivered through nasal spray, 2 doses given 28 days apart

The primary endpoint for assessment of the live attenuated vaccine take will be the AUC of the live vaccine virus shedding determined by 50% tissue culture infectious dose (TCID ) on MDCK cells at 33 degrees C nasal swabs obtained at days 2 post vaccination [clinicaltrials_resource:c0fabea4154e7b3de2267ddd2014dbee]

0.2 ml dose of live monovalent vaccine delivered through nasal spray, 2 doses given 28 days apart