An index of insulin secretion in relation to insulin resistance (IS-SI) will be calculated Change in index from baseline at 32-36 weeks,at 56 -60 weeks, and at study end (80-84 weeks) [clinicaltrials_resource:c6a1cc3f3d1961b063d1db87c0e1881d]

β-cell compensatory capacity will be evaluated by the insulin sensitivity-secretion index (IS-SI) defined as the product of composite insulin sensitivity index and first-phase insulin release index (insulinogenic index).

An index of insulin secretion in relation to insulin resistance (IS-SI) will be calculated Change in index from baseline at 32-36 weeks,at 56 -60 weeks, and at study end (80-84 weeks) [clinicaltrials_resource:c6a1cc3f3d1961b063d1db87c0e1881d]

β-cell compensatory capacity will be evaluated by the insulin sensitivity-secretion index (IS-SI) defined as the product of composite insulin sensitivity index and first-phase insulin release index (insulinogenic index).