Phase I only - Dose-limiting toxicities After 2 cycles of chemotherapy. (6 weeks after start of treatment) [clinicaltrials_resource:f4c58c7f27fec0bcc14c5a0a0b6ad35c]

Calculated as the time between the date of randomisation and date of first progression or death (from any cause), whichever occurs first. Patients who have not died or progressed will be censored at the date last seen alive (ie. the last assessment).

Phase I only - Dose-limiting toxicities After 2 cycles of chemotherapy. (6 weeks after start of treatment) [clinicaltrials_resource:f4c58c7f27fec0bcc14c5a0a0b6ad35c]

Calculated as the time between the date of randomisation and date of first progression or death (from any cause), whichever occurs first. Patients who have not died or progressed will be censored at the date last seen alive (ie. the last assessment).