Pharmacokinetic profiles determined for rifabutin, desacetyl rifabutin, rifampin, and desacetyl rifampin: Cmin Pre-dose and 2 hrs post dose in Period 2 on Days 27-30, 35 & 41. [clinicaltrials_resource:f5f1caa72994b5bb752ba6446c8170c6]

16 subjects: TMC207 400mg orally on days 1 and 29, rifabutin 300mg orally, every day on day 20-41

Pharmacokinetic profiles determined for rifabutin, desacetyl rifabutin, rifampin, and desacetyl rifampin: Cmin Pre-dose and 2 hrs post dose in Period 2 on Days 27-30, 35 & 41. [clinicaltrials_resource:f5f1caa72994b5bb752ba6446c8170c6]

16 subjects: TMC207 400mg orally on days 1 and 29, rifabutin 300mg orally, every day on day 20-41