The GTPase-activating protein Rap1GAP uses a catalytic asparagineSmall molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signallingThe complex of Arl2-GTP and PDE delta: from structure to functionStructural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteinsReassessment of the role of FKBP38 in the Rheb/mTORC1 pathwayThe retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchangeThe Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residuesSpecificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complexThe interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargoThe VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeatBiochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?Crystal structure of THEP1 from the hyperthermophile Aquifex aeolicus: a variation of the RecA fold.Identification of pyrazolopyridazinones as PDEδ inhibitors.Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopyRanGAP mediates GTP hydrolysis without an arginine fingerStructure and regulation of the cAMP-binding domains of Epac2Structural view of a fungal toxin acting on a 14-3-3 regulatory complexPhosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesisStructural evidence for a common intermediate in small G protein-GEF reactionsStructure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopyStructural insight into filament formation by mammalian septinsThe crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complexStructure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinaseSpecificity of Interactions between mDia Isoforms and Rho ProteinsA structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin AGTP-induced conformational changes in septins and implications for functionA restricted spectrum of NRAS mutations causes Noonan syndromeStabilizing a weak binding state for effectors in the human ras protein by cyclen complexesThe structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanismStructural and biochemical properties of Sept7, a unique septin required for filament formationStructural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarityArl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargoRoco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutationsStructural insights into the small G-protein Arl13B and implications for Joubert syndromeC2 domains as protein-protein interaction modules in the ciliary transition zoneRevisiting the Roco G-protein cycleStructural Characterization of LRRK2 Inhibitors
P50
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P50
description
Duits biochemicus
@nl
German biochemist
@en
bioquímicu alemán
@ast
bithchemiceoir Gearmánach
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deutscher Biochemiker
@de
عالم كيمياء حيوية ألماني
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name
Alfred Wittinghofer
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Alfred Wittinghofer
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Alfred Wittinghofer
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Alfred Wittinghofer
@de
Alfred Wittinghofer
@en
Alfred Wittinghofer
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Alfred Wittinghofer
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Alfred Wittinghofer
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Alfred Wittinghofer
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Alfred Wittinghofer
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type
label
Alfred Wittinghofer
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Alfred Wittinghofer
@ca
Alfred Wittinghofer
@da
Alfred Wittinghofer
@de
Alfred Wittinghofer
@en
Alfred Wittinghofer
@es
Alfred Wittinghofer
@fr
Alfred Wittinghofer
@it
Alfred Wittinghofer
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Alfred Wittinghofer
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prefLabel
Alfred Wittinghofer
@ast
Alfred Wittinghofer
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Alfred Wittinghofer
@da
Alfred Wittinghofer
@de
Alfred Wittinghofer
@en
Alfred Wittinghofer
@es
Alfred Wittinghofer
@fr
Alfred Wittinghofer
@it
Alfred Wittinghofer
@nb
Alfred Wittinghofer
@nl
P166
P463
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0000 0003 6761 1677
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1943-01-01T00:00:00Z
1943-05-23T00:00:00Z
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