about
P688
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleusMagicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG developmentTumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivatorsThe Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulationJCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumorsConditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumorsA growing family of Notch ligandsNF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctionsWidespread but cell type-specific expression of the mouse neurofibromatosis type 2 geneMerlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 proteinLocalization and functional domains of the neurofibromatosis type II tumor suppressor, merlinThe tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens
P921
Q24300770-6726BEBC-D0C8-4494-96B6-88873B175100Q24306359-00DA55E6-2E6E-4D34-B410-4CABAA6E4D7AQ24307540-E6AB83B7-2DAA-45CB-B645-79B21EE220A1Q28504464-EB7CCA64-837A-4971-AC49-76F568119956Q28504969-0682383B-CCDC-4552-8A8B-306C30BE80FFQ28506719-B9898626-8537-4C1D-AACE-B8E88096474BQ28507503-A30A334A-2B21-43AF-84C3-8A0E429399BCQ28510087-A4704D1B-2463-45D3-8AB3-7202ED98732DQ28510402-1EF77F20-114F-466A-A283-281C094A15C0Q28511556-522BA580-0108-42FA-9F60-04F7825B656DQ28511997-74EC9425-E84E-40CF-931D-42D99D40C954Q28513718-E290FBA1-C989-4947-A055-E4895740A6B9Q28587255-F06508F4-F886-4AC2-B1F6-E570649F3172Q28587944-10DEDEEC-8D33-4895-9A36-C4D699117C51Q28590774-C9A98D5B-4F5C-431B-8005-585163F22AA7
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Neurofibromin 2
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Neurofibromin 2
@en
type
label
Neurofibromin 2
@en
altLabel
Neurofibromin-2
@en
Nf2
@en
merlin
@en
moesin-ezrin-radixin-like protein
@en
neurofibromatosis 2
@en
schwannomin
@en
prefLabel
Neurofibromin 2
@en
P361
P527
P637
P638
P680
P681
P682
P705
P352
P486
P637
P31
P352
P361
P486
P527
P637
NP_001239179
NP_001239180
NP_001239181
NP_001239182
NP_001348604
NP_001348605
NP_001348606
XP_006514632
XP_006514633
P638
P680
P681
P682
P702
P703
P705
ENSMUSP00000055033
ENSMUSP00000055061
ENSMUSP00000091066
ENSMUSP00000105536
ENSMUSP00000116505
ENSMUSP00000128494
ENSMUSP00000129388
ENSMUSP00000130263
ENSMUSP00000132184