Multiple endocrine neoplasia 1

Multiple endocrine neoplasia 1

Item
http://www.wikidata.org/entity/Q14913043
Men1
P688
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locusMenin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunDMenin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitorsThe tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesisMEN1 tumor-suppressor protein localizes to telomeres during meiosisCharacterization of the mouse Men1 gene and its expression during developmentMenin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4cTumor suppressor menin regulates expression of insulin-like growth factor binding protein 2Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in miceMenin prevents liver steatosis through co-activation of peroxisome proliferator-activated receptor alphaSTAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cellsMenin is required in cranial neural crest for palatogenesis and perinatal viabilityp18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancersMutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cellsBroad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1Menin induces apoptosis in murine embryonic fibroblastsHistone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissuesA mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumorsMenin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitusParathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidismmiR-24 regulates menin in the endocrine pancreas
P921
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P921

Multiple endocrine neoplasia 1

Item
http://www.wikidata.org/entity/Q14913043
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Multiple endocrine neoplasia 1
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Multiple endocrine neoplasia 1
@en
Multiple endocrine neoplasia 1
@nl
type
label
Multiple endocrine neoplasia 1
@en
Multiple endocrine neoplasia 1
@nl
altLabel
Men1
@en
menin
@en
uniprot:O88559
@en
prefLabel
Multiple endocrine neoplasia 1
@en
Multiple endocrine neoplasia 1
@nl
P279
P31
P352
P361
P637
P680
P681
P682
P702
P703
P705
P352
P637
P279
P31
P352
P361
P637
P680
P681
P682
P702
P703
P705