SMAD2;3:SMAD4:FOXO3:FoxO3a-binding ElementFOXO1;FOXO3;FOXO4;(FOXO6)p-FOXO1;p-FOXO3;p-FOXO4RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:FOXO3:BCL2L11 geneSTAT3-upregulated nuclear proteinsPhospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elementsCDK5:p25 phosphorylates FOXO3Phosphorylated FOXO3 translocates to the nucleusBCL2L11 (BIM) gene expressionFASLG (FasL) gene expressionExpression of superoxide dismutase 2APP gene expressionRUNX3 binds the BCL2L11 (BIM) genep-T182 MAPKAPK5 phosphorylates FOXO3p-S215 FOXO3 translocates to the nucleus
P527
P688
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorThe MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesisFoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1Foxo3a regulates apoptosis by negatively targeting miR-21BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesisIkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3aA conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life spanCHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stressLacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolismA novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.
P921
Q50255089-6690EE22-FC6B-490C-B0B9-6291559A883BQ50255944-79E8DD13-6E71-4651-ADCC-1A3294459AA4Q50255945-253E355A-05A8-4E0A-B299-2BE99C8DF94BQ50258570-DE7CDF35-21E3-41F3-8470-53670A62E385Q50263051-9E1D85C1-DB0D-49C3-9701-F3CB6C915F31Q50287876-17F3CE0C-E727-4651-A564-FBFEE82CF728Q50289698-7A392076-29D7-4D0B-A16F-7E11B58107D7Q50289698-A48844A8-FBBC-44FF-A3F4-C09D7BDDFAD8Q50289700-01710B92-E5C7-4E58-988B-6DE6CBB77B69Q50289700-9A9132FD-BDA0-408C-8766-1CC0221DB762Q50289702-FED0B8A3-F724-4637-AA64-09C2AF5F0DD5Q50289703-C457D91E-4FB0-4917-A2F9-4B831E23319FQ50289704-198F4130-8746-46D2-9DF4-71B9329F4402Q50289706-FDFCB5B9-EED7-47FA-B99E-6B7A2B708401Q50290775-4DB9EC7A-10F7-4CC2-AE50-BAFBBC53F865Q50299051-D00527EA-8C7E-4DBD-BF17-1ABDB783DB1BQ50299054-8F1DD1A0-BDE1-4B82-ADAF-66A3BA14D3AAQ50299054-9EC6ACE5-DAAB-46DF-82F7-2838C5DAC1FC
P527
Q22009126-AA1B997F-A402-4B8D-B5E3-D237154349C8Q24293460-81703094-0C2D-4433-984E-E4F654BB9485Q24305481-C9C0D42D-0578-446F-9E3B-0A09FDF557DEQ24305974-6C8CFE13-6EA5-4DB0-B587-69025E6CC889Q24312066-D48CA852-E388-4DCD-8968-D7E11B46B515Q24336832-73F066E9-95A3-4BFF-972B-F529DD74B1BBQ24338599-E6471109-326D-4EE0-AF7B-537FD89995E4Q24339500-03EE640A-924B-4F98-ABB5-EB19F00735F6Q24609781-7316987B-36CD-4FA5-9CB2-9F967C7DD176Q42827279-107F830D-D90C-4E20-A337-3D713B640FE1Q50315356-827BDE0D-BBA4-43A9-AA47-EF617FD8D4B7
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Forkhead box O3
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
FOXO3
@cy
FOXO3
@it
FOXO3
@pt
FOXO3
@uk
FOXO3A
@fr
Forkhead box O3
@en
Forkhead box O3
@nl
Forkhead-Box-Protein O3
@de
type
label
FOXO3
@cy
FOXO3
@it
FOXO3
@pt
FOXO3
@uk
FOXO3A
@fr
Forkhead box O3
@en
Forkhead box O3
@nl
Forkhead-Box-Protein O3
@de
altLabel
AF6q21 protein
@en
FOXO3
@en
forkhead box O3A
@en
forkhead box protein O3
@en
forkhead homolog (rhabdomyosarcoma) like 1
@en
forkhead in rhabdomyosarcoma-like 1
@en
forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
@en
prefLabel
FOXO3
@cy
FOXO3
@it
FOXO3
@pt
FOXO3
@uk
FOXO3A
@fr
Forkhead box O3
@en
Forkhead box O3
@nl
Forkhead-Box-Protein O3
@de
P361
P527
P637
P638
P680
P681
P682
P705
P352
P486
P6366
P637
P31
P352
P361
P486
D000071316
P6366
P637
XP_005266924
XP_005266925
XP_011533928
XP_011533930
XP_011533931
XP_016866074
XP_016866075
P638
P680
P681
P682
P702
P703
P705
ENSP00000339527
ENSP00000385824
ENSP00000446316