P688
Immune signaling by RIG-I-like receptorsRegulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virusPCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinaseMDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signalingSolution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptorsActivation of MDA5 requires higher-order RNA structures generated during virus infectionStructural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune responseDHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cellsCooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition
P921
Q24304438-47DEBB3F-8350-4048-A094-CE5FFA1100AFQ24310270-2B3326A3-A84D-47CD-AE2C-B66D3CBA5626Q24311228-F7166986-7844-4F20-B7C2-93415DA8D8B6Q24313563-4D3E9B70-B94B-4923-AD21-EEF3CE0E114DQ24315702-457A71E0-ACBA-4F79-AFDF-9C403B3145DCQ24316163-D0B7119A-26B3-442D-A09B-3D8AD74898A3Q24317636-A1D41AB0-E550-4D36-817B-80D90EB48FAAQ24321400-D789864D-6B3E-47DF-9566-87EE80462646Q24338545-2A4D4419-2E9D-43D4-8481-1D356C2D5761Q28596610-7CEEF191-64DA-4F16-A9B7-08A35A22B3FFQ30179446-B842EB6E-9E43-4B68-8E1A-CFE8350D4873Q35641310-724920BB-F308-4E76-BFCF-59B3A77079B0
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteinë
@sq
proteïne in Interferon induced with helicase C domain 1
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
IFIH1
@cy
IFIH1
@uk
Interferon induced with helicase C domain 1
@en
Interferon induced with helicase C domain 1
@nl
MDA5
@de
MDA5
@ru
type
label
IFIH1
@cy
IFIH1
@uk
Interferon induced with helicase C domain 1
@en
Interferon induced with helicase C domain 1
@nl
MDA5
@de
MDA5
@ru
altLabel
CADM-140 autoantigen
@en
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
@en
IFIH1
@en
Interferon-induced with helicase C domain protein 1
@en
MDA-5
@en
RIG-I-like receptor 2
@en
RLR-2
@en
RNA helicase-DEAD box protein 116
@en
clinically amyopathic dermatomyositis autoantigen 140 kDa
@en
helicard
@en
prefLabel
IFIH1
@cy
IFIH1
@uk
Interferon induced with helicase C domain 1
@en
Interferon induced with helicase C domain 1
@nl
MDA5
@de
MDA5
@ru
P527
P638
P680
P681
P682
P352
P486
P6366
P637
P31
P352
P361
P486
D000072640
P527
P6366
P637
P638
P680
P682
P702
P703
P705
ENSP00000263642
ENSP00000408450