High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism - Test2 - elhamkhani - TriplyDB

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

http://www.wikidata.org/entity/Q21131409

about

A multi-level multi-scale approach to study essential genes in Mycobacterium tuberculosis Pathogen roid rage: cholesterol utilization by Mycobacterium tuberculosis The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Building a better bacillus: the emergence of Mycobacterium tuberculosis Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis Translating genomics research into control of tuberculosis: lessons learned and future prospects Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis Increasing the structural coverage of tuberculosis drug targets Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria Crystal Structure of Mycobacterium tuberculosis Polyketide Synthase 11 (PKS11) Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis Structural and Biochemical Analyses of Mycobacterium tuberculosis N-Acetylmuramyl-L-alanine Amidase Rv3717 Point to a Role in Peptidoglycan Fragment Recycling Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases Structural analysis of Mycobacterium tuberculosis ATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors A structural and functional investigation of a novel protein from Mycobacterium smegmatis implicated in mycobacterial macrophage survivability Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance Mycobacterial genes essential for the pathogen's survival in the host Shrinking the FadE proteome of Mycobacterium tuberculosis: insights into cholesterol metabolism through identification of an α2β2 heterotetrameric acyl coenzyme A dehydrogenase family Identification and in vitro analysis of the GatD/MurT enzyme-complex catalyzing lipid II amidation in Staphylococcus aureus Global assessment of genomic regions required for growth in Mycobacterium tuberculosis Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides A novel role of the PrpR as a transcription factor involved in the regulation of methylcitrate pathway in Mycobacterium tuberculosis Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis Pleiotropic effect of AccD5 and AccE5 depletion in acyl-coenzyme A carboxylase activity and in lipid biosynthesis in mycobacteria Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway Diversity of Mycobacterium tuberculosis across Evolutionary Scales Integrated Modeling of Gene Regulatory and Metabolic Networks in Mycobacterium tuberculosis Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis

P2860

Q21202770-13BB070F-3048-44B0-80D8-1974FAB94D52 Q22305694-C67452E5-9CFF-4120-AD30-615776A1FA86 Q26795478-1E3AAAD2-3205-40E7-A6DD-EDB002B38B01 Q26826809-38F8BED9-160B-4B8C-8B69-B74ACA33B4F4 Q27003186-012FC292-88E1-468D-A110-B4C08BD1D98A Q27023437-41CAACAA-30A7-4D65-899F-E3D51EC2D6EA Q27644255-1383B588-1B98-43B3-9744-B001B7489862 Q27644314-DBBC301E-09B2-42F8-A334-07921BB0F130 Q27675581-E5097B6D-C96C-497A-8160-50AF8E005FDF Q27676873-C84AC0D5-85A1-4F6E-BE2F-BC1F921E004D Q27677552-6F6A0A42-1A62-4366-BF32-0B046B7E3437 Q27678803-AFA2ACB5-B835-4FEA-8D50-ECC3DC81EF83 Q27679907-B012BD03-C711-45E3-AD91-8F07E352316B Q27680218-24F54EE1-A3EB-4BE9-9152-948CBBACABE8 Q27684009-FD2C96FB-5A75-4181-ADB1-C1416232246E Q27687788-4960EA19-C376-48C6-B624-A0FCD752D7C5 Q27688947-AED57D83-D5D7-4D92-98B9-2157015F876F Q27689784-38D1A2CC-9AEB-42A2-B282-A4F46CC2817A Q27690716-5C96BA68-B4F5-4340-BF1B-111104F3E509 Q27695573-FF576A48-5BC2-49F8-A996-730143526BAC Q27704017-AD40740D-FABF-45DE-A488-A597E58896B6 Q27728459-E7C6309E-8393-481D-9D5E-BE91823D499B Q28082718-690FA115-8AC3-4303-B4D9-32923222946E Q28083739-57672863-6CAB-432D-9011-E7674A22891C Q28294215-9C081E57-E4E9-4F90-AEDD-705128AB4E33 Q28480400-E7566A82-4ED9-41E3-A0E0-3E1E51AC7038 Q28484097-3B248F74-23E9-435E-A06D-ADA0CD413A4F Q28486781-B7646595-D516-43A2-8546-5226B064F37E Q28487006-14B114EE-B89A-4066-B364-07CDA7C061BD Q28487434-5F982147-501E-444D-9429-34A359D20B03 Q28487476-982F5798-12BB-4D0B-9949-475149AC3CB8 Q28487581-26E34B49-4B1F-4073-A736-25922FAE877F Q28533721-10BB62B3-5B89-4C73-B90A-10732D3AF2C8 Q28539080-D8220D69-0340-4CA0-8625-880C9236831C Q28539884-A22376A9-D27E-4C00-AEA0-D0745A946574 Q28543091-B6ED2E1A-C463-4D8D-B9C1-C8C78B1511CA Q28550914-4A678942-21AF-4CDA-AC61-EF17B31B5FBA Q28551193-8E7B1102-10AE-445E-87CC-6B7F387E28CC Q28551386-69A1E6A5-C622-49F9-87C3-63D9ECFBF6AC Q28552338-C1FA4581-231B-46F4-8092-0BCFB5E7EB4A

P2860

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

http://www.wikidata.org/entity/Q21131409

description

2011 nî lūn-bûn

@nan

2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@ast

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@en

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@en-gb

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@nl

type

label

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@ast

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@en

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@en-gb

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@nl

altLabel

High-Resolution Phenotypic Pro ...... wth and Cholesterol Catabolism

@en

prefLabel

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@ast

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@en

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@en-gb

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@nl

P1433

Q21131409-51C207B4-2308-42C8-9C8D-CC1C995A061E

P1476

Q21131409-75BE5B38-E85C-4234-8627-4E93139CF9EC

P2093

Q21131409-12500015-F29E-498D-86BE-1FBD1F0EF4B6

Q21131409-1D9DF075-A9F8-4B1D-A8F6-475A0D282169

Q21131409-2891A92F-9C17-4537-9A4A-0DFE0337470C

Q21131409-47CD0F3F-C903-4844-A69F-1290C826BF81

Q21131409-4F08ADC9-72C9-42EF-ACDC-05E8810E1C86

P2860

Q21131409-02970CA2-ABAC-4C52-85A2-D45F944053E8

Q21131409-09BC6CCE-1776-45EB-8661-D89AE5BEA43B

Q21131409-0A477D15-686B-491C-8560-B83170CCF124

Q21131409-0AD18B7F-BF9E-4B31-BFB3-105CF5E74F11

Q21131409-0D8C0367-B80D-4188-9C46-C9C0E784EA93

Q21131409-0FDDA75E-37B6-47CA-8173-122BD17FF9C6

Q21131409-109BD9A9-1087-462B-862E-93DF6D10C26B

Q21131409-129F0771-F243-4F71-8713-0974378CE73F

Q21131409-132A8FE5-2E36-4E85-97FA-ECC2032BC102

Q21131409-1346C3C8-E44A-474B-9F67-DD128D3EE573

P304

Q21131409-77EABCB2-C88D-4AF1-98BF-088817A5507C

P31

Q21131409-B8E0177F-2D2E-4F92-8438-197043E17B75

P3181

Q21131409-159330FD-4839-46D1-B48A-7854ECEDC0AD

P356

Q21131409-8ED90573-1B89-4FD7-8793-B32ED4B46C69

P407

Q21131409-69953DF4-6764-41F2-86A4-D4C1627E891A

P433

Q21131409-9FE04AA1-EABC-4B44-BD25-318373DFC499

P478

Q21131409-AF0462D0-8478-4033-8F8B-9C98F0F4683E

P50

Q21131409-198F25F1-854F-4A51-B328-BD6144CC7F1E

P577

Q21131409-69BAC9CE-3903-4888-84F8-FF0BD6BD2F1A

P5875

Q21131409-778A1318-4F1B-4561-A2B3-1FEEEAB2F18E

P698

Q21131409-4B36BBF1-D34D-406F-996B-A868B78E5381

P932

Q21131409-0BFCA036-EFA8-4856-9D33-82B4D64CE5EB

P3181

P356

JOURNAL.PPAT.1002251

P1433

P1476

High-resolution phenotypic pro ...... wth and cholesterol catabolism

@en

P2093

Brian J Akerley

http://www.w3.org/2001/XMLSchema#string

Christopher M Sassetti

http://www.w3.org/2001/XMLSchema#string

Jeffrey D Gawronski

http://www.w3.org/2001/XMLSchema#string

Jennifer E Griffin

http://www.w3.org/2001/XMLSchema#string

Thomas R Ioerger

http://www.w3.org/2001/XMLSchema#string

P2860

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

Comprehensive identification of conditionally essential genes in mycobacteria

Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one

Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids

Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells

Systematic identification of essential genes by in vitro mariner mutagenesis

Genes required for mycobacterial growth defined by high density mutagenesis

SOAP: short oligonucleotide alignment program

P304

e1002251

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

396461

http://www.w3.org/2001/XMLSchema#string

P356

10.1371/JOURNAL.PPAT.1002251

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

Michael A Dejesus

P577

2011-09-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51699949

http://www.w3.org/2001/XMLSchema#string

P698

21980284

http://www.w3.org/2001/XMLSchema#string

P932

3182942

http://www.w3.org/2001/XMLSchema#string