Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response - Test2 - elhamkhani - TriplyDB

Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response

Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response

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In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells Viral evolution and escape during acute HIV-1 infection Role of HLA Adaptation in HIV Evolution Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs Mechanisms of HIV protein degradation into epitopes: implications for vaccine design Evolutionary analysis of human immunodeficiency virus type 1 therapies based on conditionally replicating vectors HIV-1 Env C2-V4 diversification in a slow-progressor infant reveals a flat but rugged fitness landscape Fitness costs of mutations at the HIV-1 capsid hexamerization interface Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage HIV-1 Genetic Variability and Clinical Implications The HIV-1 pandemic: does the selective sweep in chimpanzees mirror humankind's future?Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection.Spin models inferred from patient-derived viral sequence data faithfully describe HIV fitness landscapes A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques.Phylogenetic analysis of population-based and deep sequencing data to identify coevolving sites in the nef gene of HIV-1.Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.Immune escape mutations detected within HIV-1 epitopes associated with viral control during treatment interruption Dynamics of viral evolution and CTL responses in HIV-1 infection Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus Daily sampling of an HIV-1 patient with slowly progressing disease displays persistence of multiple env subpopulations consistent with neutrality The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.Identifying and characterizing recently transmitted viruses.Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1 Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters Relative replication capacity of phenotypic SIV variants during primary infections differs with route of inoculation.Estimating the fitness cost of escape from HLA presentation in HIV-1 protease and reverse transcriptase.Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design.MRKAd5 HIV-1 Gag/Pol/Nef vaccine-induced T-cell responses inadequately predict distance of breakthrough HIV-1 sequences to the vaccine or viral load.Commentary on the role of treatment-related HIV compensatory mutations on increasing virulence: new discoveries twenty years since the clinical testing of protease inhibitors to block HIV-1 replication.Immunogenetics of small ruminant lentiviral infections Induction of immunity to human immunodeficiency virus type-1 by vaccination.The T-cell response to HIV.Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1.Dissecting the dynamics of HIV-1 protein sequence diversity.Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation.Stem cell-based anti-HIV gene therapy.Extreme genetic fragility of the HIV-1 capsid.Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques

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Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response

http://www.wikidata.org/entity/Q21131580

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2009 nî lūn-bûn

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2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Variable fitness impact of HIV ...... ic T lymphocyte (CTL) response

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Awet Abraha

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Denis M Tebit

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Eric J Arts

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Ryan M Troyer

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Santiago Avila

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P2860

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

Quantifying the uncertainty in forecasts of anthropogenic climate change

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss

Structure of a V3-containing HIV-1 gp120 core

RNA virus mutations and fitness for survival

A dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progression.

Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost

HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load

Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution

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