Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA
about
Nucleotide excision repair in eukaryotesPDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δPersistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.XPA: A key scaffold for human nucleotide excision repair.Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent mannerTargeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells.The RASSF1A tumor suppressor regulates XPA-mediated DNA repairIncreased Anticancer Efficacy of Intravesical Mitomycin C Therapy when Combined with a PCNA Targeting Peptide.A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cellsProgerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes.The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates.Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency.PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions.FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.Paracrine regulation of melanocyte genomic stability: a focus on nucleotide excision repair.Regulation and Modulation of Human DNA Polymerase δ Activity and Function.RPA and XPA interaction with DNA structures mimicking intermediates of the late stages in nucleotide excision repair.Structural analyses of the bacterial primosomal protein DnaB reveal that it is a tetramer and forms a complex with a primosomal re-initiation protein.Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer."Two hits - one stone"; increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling
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P2860
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA
description
2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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Nucleotide excision repair is ...... teraction between XPA and PCNA
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Nucleotide excision repair is ...... teraction between XPA and PCNA
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Nucleotide excision repair is ...... teraction between XPA and PCNA
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Nucleotide excision repair is ...... teraction between XPA and PCNA
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Nucleotide Excision Repair Is ...... teraction between XPA and PCNA
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Nucleotide excision repair is ...... teraction between XPA and PCNA
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Nucleotide excision repair is ...... teraction between XPA and PCNA
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Karin M Gilljam
Nina B Liabakk
Rebekka Müller
P2860
P304
P356
10.1371/JOURNAL.PONE.0049199
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P577
2012-01-01T00:00:00Z