about
The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferonsJanus kinases in immune cell signalingEfficacy and safety of the oral Janus kinase inhibitor peficitinib (ASP015K) monotherapy in patients with moderate to severe rheumatoid arthritis in Japan: a 12-week, randomised, double-blind, placebo-controlled phase IIb studyIntegrating Immunologic Signaling Networks: The JAK/STAT Pathway in Colitis and Colitis-Associated CancerJAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsSignal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug DiscoveryTargeting JAK2 in the therapy of myeloproliferative neoplasmsInteraction of JAK with steroid receptor functionEnabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitorContribution of chaperones to STAT pathway signaling.Covalent docking of large libraries for the discovery of chemical probesRestoration of IFNγR subunit assembly, IFNγ signaling and parasite clearance in Leishmania donovani infected macrophages: role of membrane cholesterolProtein tyrosine phosphatases in the JAK/STAT pathwayTYK2 kinase activity is required for functional type I interferon responses in vivoSignal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity.RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia.Molecular characterization of human breast tumor vascular cells.JAK2 V617F in myeloid disorders: what do we know now, and where are we headed?Selective Janus associated kinase 1 inhibition as a therapeutic target in myelofibrosis.Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair.HDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target?Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways.Future therapeutic targets in rheumatoid arthritis?Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats.Activation of JAK2-V617F by components of heterodimeric cytokine receptorsAn N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malariaGenetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study.JAK inhibition for the treatment of rheumatoid arthritis: a new era in oral DMARD therapy.AZD1480 delays tumor growth in a melanoma model while enhancing the suppressive activity of myeloid-derived suppressor cells.Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cellsThe arrival of JAK inhibitors: advancing the treatment of immune and hematologic disorders.The Jak/STAT signaling pathway is downregulated at febrile temperatures.The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation.Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.Arabidopsis L-type lectin receptor kinases: phylogeny, classification, and expression profiles.6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.JAK2-centered interactome hotspot identified by an integrative network algorithm in acute Stanford type A aortic dissectionCurcumin suppresses the production of interleukin-6 in Prevotella intermedia lipopolysaccharide-activated RAW 264.7 cells.Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivoInterferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականին հրատարակուած գիտական յօդուած
@hyw
2004 թվականին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
The Janus kinases (Jaks)
@ast
The Janus kinases (Jaks)
@en
The Janus kinases (Jaks)
@en-gb
The Janus kinases (Jaks)
@nl
type
label
The Janus kinases (Jaks)
@ast
The Janus kinases (Jaks)
@en
The Janus kinases (Jaks)
@en-gb
The Janus kinases (Jaks)
@nl
prefLabel
The Janus kinases (Jaks)
@ast
The Janus kinases (Jaks)
@en
The Janus kinases (Jaks)
@en-gb
The Janus kinases (Jaks)
@nl
P2093
P2860
P3181
P356
P1433
P1476
The Janus kinases (Jaks)
@en
P2093
John J O'Shea
Kunihiro Yamaoka
Marko Pesu
Vance E T Holt
P2860
P2888
P3181
P356
10.1186/GB-2004-5-12-253
P407
P577
2004-01-01T00:00:00Z
2004-11-30T00:00:00Z
P5875
P6179
1016313034