Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles
about
Evolution in eggs and phases: experimental evolution of fecundity and reproductive timing in Caenorhabditis elegansCancer susceptibility and reproductive trade-offs: a model of the evolution of cancer defencesProperties of human disease genes and the role of genes linked to Mendelian disorders in complex disease aetiology.Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropyRapid evolution of BRCA1 and BRCA2 in humans and other primates.Current evolutionary adaptiveness of psychiatric disorders: Fertility rates, parent-child relationship quality, and psychiatric disorders across the lifespanFibrosis: ultimate and proximate causesPleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein.Differential regulation of antagonistic pleiotropy in synthetic and natural populations suggests its role in adaptation.Information theoretical analysis of aging as a risk factor for heart diseaseThe genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast.Androgen receptor polyglutamine repeat number: models of selection and disease susceptibility.Epigenetic assimilation in the aging human brainAn Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression.Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression.A framework for how environment contributes to cancer risk.Designing babies through gene editing: science or science fiction?Differential Regulation of Cryptic Genetic Variation Shapes the Genetic Interactome Underlying Complex TraitsPleiotropy of the de novo-originated gene MDF1.Molecular Basis of Overdominance at a Flower Color Locus.Antagonistic pleiotropy can maintain fitness variation in annual plants.A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.Specific alleles at immune genes, rather than genome-wide heterozygosity, are related to immunity and survival in the critically endangered Attwater's prairie-chicken.Testing for beneficial reversal of dominance during salinity shifts in the invasive copepod Eurytemora affinis, and implications for the maintenance of genetic variation.Combination of 247 genome-wide association studies reveals high cancer risk as a result of evolutionary adaptation.Women's attractiveness is linked to expected age at menopause.Genetic architecture: the shape of the genetic contribution to human traits and disease.Convergence between biological, behavioural and genetic determinants of obesity.Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE.Developmental constraint through negative pleiotropy in the zygomatic arch.Comparative Serum Challenges Show Divergent Patterns of Gene Expression and Open Chromatin in Human and Chimpanzee.Apolipoprotein E (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?Does the Cost of Adaptation to Extremely Stressful Environments Diminish Over Time? A Literature Synthesis on How Plants Adapt to Heavy Metals and PesticidesHorizons in the evolution of aging
P2860
Q28584737-6107472B-9C42-4598-9589-AA8F4D39195DQ28607310-23D67191-34C8-432D-867D-61856653410BQ33614650-3446118C-F5F8-40DF-AB1D-9ABD22886A4CQ33825082-753E15EB-F844-4ACB-9449-5030AD16D843Q33930642-1CE49C2D-3A21-4AA0-86A9-2748814977C4Q34532410-F82C1119-D2E9-49A7-A891-ED5F17A02A22Q35140034-BFB99A87-6B54-4709-865E-EAAAB3C87AA6Q35175180-D734A24E-A3C8-4CAA-80A6-9D9C96692306Q35589947-ACC46183-A0F6-4137-95D4-B5E57A34E1B9Q35636879-130F035E-EF75-4722-817A-DE0C75FD9E74Q36442608-EAE11C69-E5EA-45CC-8A88-A3A6D85576ECQ36651700-11F1B579-FB56-4533-96CD-A8DC8D0FAAFBQ36846684-CFA7A8CC-21B3-4B97-B904-5574298B886AQ37396874-4E479993-5A5E-4EBC-A7D6-49B77A1D6180Q40196315-8192BA8D-41F1-4D8E-9775-C2D896EA701EQ40379657-750DE3E4-779E-4714-B235-C21E3E0CC0A3Q40813051-29BEC0BD-EAFF-4CD7-A343-7DA094538528Q41897731-2FB46874-E84E-4928-A3DC-6C559A4FE0F3Q43049008-FBB7AEAE-0EBA-492A-AAD6-527BD3B6BBD8Q46280093-5C5D1E1D-9E12-482B-B141-F3D51AABAFFEQ46286020-B601A4EE-C212-44E1-9201-9F2E2040CCACQ46311792-01E970B7-2497-4A8B-A12B-5C89703367D6Q46507062-59B1EA04-1A36-483C-A6F9-3251420C3B08Q46850700-440272AC-1676-4616-B110-6DE82AC0552CQ47343132-AE402F11-BEBA-48F1-A1CB-6532D5C7AEFDQ47572468-47B443E9-A8F0-4ACC-8AB3-91F15ED50A7AQ47579970-D21B9CD6-9C3D-48A0-8417-5F4C72390B04Q47841719-C6FD3E43-E962-4E9B-BACB-21D1607F5816Q48257215-CF75C03B-D99F-46B2-BC19-AC31F2BF9560Q49166293-2B04704C-DFBE-4FD4-B162-2223DF38C587Q52722269-82F12CC8-514B-47D4-B504-4FA3F5A71ACCQ55668951-1A6C156D-1BE0-4114-9098-42D6B96B7218Q57067448-78EF0E5D-6500-40CF-96BB-F6D08ED3CA95Q58765738-F00AE590-10DC-48A7-87E8-A3C548908CAB
P2860
Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@ast
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@en
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@en-gb
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@nl
type
label
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@ast
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@en
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@en-gb
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@nl
prefLabel
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@ast
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@en
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@en-gb
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@nl
P2860
P3181
P356
P1433
P1476
Antagonistic pleiotropy as a w ...... of polymorphic disease alleles
@en
P2093
Andrew Q Nguyen
Ashley J R Carter
P2860
P2888
P3181
P356
10.1186/1471-2350-12-160
P407
P577
2011-01-01T00:00:00Z
P5875
P6179
1020722549