about
P688
Negative control of p53 by Sir2alpha promotes cell survival under stressBrown remodeling of white adipose tissue by SirT1-dependent deacetylation of PparγSirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gammaThe direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylationSIRT1 deacetylates and positively regulates the nuclear receptor LXRSIRT1 activates MAO-A in the brain to mediate anxiety and exploratory driveDYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formationAngiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cellsRegulation of unfolded protein response modulator XBP1s by acetylation and deacetylationTranscriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivationSIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1SIRT1 regulates circadian clock gene expression through PER2 deacetylationSirtuins deacetylate and activate mammalian acetyl-CoA synthetasesThe NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian controlCircadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesisSIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicityReversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencingSIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesityGAPDH mediates nitrosylation of nuclear proteinsA nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expressionMetastasis-associated protein 1 is an integral component of the circadian molecular machinerySIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylationBCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targetsSIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restrictionHistone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
P921
Q24291828-D237107E-C6D6-4CD1-B7DD-5839838DA7AFQ24294883-57691941-05EF-484F-A65F-82D6FD4ABF5AQ24294948-BEFCD160-77BF-4E0A-8D8C-2C4F63F8080FQ24295143-3146E154-C7BD-4C91-A6FF-A50973B45278Q24297669-85741BC3-7ACC-4C9A-86E4-5AB9BE027628Q24299792-54A265F7-E995-4844-9EC9-380EC8BC81CBQ24300074-5ADC2B8A-1F57-4A8F-BB94-0B0ADDAEDAAEQ24300487-92C23D4E-9953-4459-B0E8-74DF3FBF7423Q24300671-FA95AEC2-2990-409D-BB5A-AD5DA8431C21Q24301843-7A69E7CF-D41C-4B0E-9D96-05E4A4EDD18BQ24303825-39BCDF7D-29FC-4EC8-8AEB-484383EAD78BQ24306100-B18FA31C-906D-4683-BE9D-027624706622Q24314439-8862F628-B1A4-4435-BD9E-4C8170371ADFQ24317933-6B4EFC64-1FD9-4890-8C0D-AAEE7EE89AEDQ24548362-4B14E042-B614-4A15-B6FE-F41567C9F2ADQ24597971-9390D538-5D16-4BF7-9753-757DE135FF7AQ24658408-21F2E644-E330-4ABD-A20F-BDC269210428Q28235481-4976ADFC-9B7B-4471-B6D8-D88262097DACQ28237795-A8347438-FCBD-4DC4-BBDC-33048FEEF3DBQ28507004-26E1E27A-83EB-4756-904F-42A91601381DQ28508559-05D6265B-F51A-447E-ABAB-B6C105C8F0AEQ28512048-23B652E4-B6F4-41E9-A8AD-CC0C16590D85Q28569676-139238EF-588A-4EEC-ABDE-D5E4EB6D61FAQ28586675-D3D25DA7-C4ED-4912-A023-DC3E24E9E821Q28587594-44ABCF0E-B319-45ED-B447-13DC0529BAF0Q28589415-0A8875F2-E95A-4109-91AB-596CACFF3A7BQ28591152-46ED3AA7-AB9B-4049-9AB3-DAFA31A624ADQ28591910-49ECD32C-277B-4244-892E-727383A19CE9Q30483969-DD3815CF-D6D4-45CA-AC53-363D1DAA48B6Q61136132-589256C0-1183-455E-BA7F-666E30626682
P921
description
Säugetierprotein
@de
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Sirtuin 1
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Sirtuin 1
@en
type
label
Sirtuin 1
@en
altLabel
NAD-dependent protein deacetylase sirtuin-1
@en
SIR2-like protein 1
@en
SIR2alpha
@en
Sir2
@en
Sirt1
@en
mSIR2a
@en
regulatory protein SIR2 homolog 1
@en
sirtuin 1 ((silent mating type information regulation 2, homolog) 1
@en
prefLabel
Sirtuin 1
@en
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NP_001153061
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ENSMUSP00000020257
ENSMUSP00000101082
ENSMUSP00000112595
ENSMUSP00000117819
ENSMUSP00000137565