Herpes simplex virus 2 ICP0 mutant viruses are avirulent and immunogenic: implications for a genital herpes vaccine
about
A live-attenuated HSV-2 ICP0 virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccineNovel roles of cytoplasmic ICP0: proteasome-independent functions of the RING finger are required to block interferon-stimulated gene production but not to promote viral replication.Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in αßγ interferon receptor-deficient mice.Pan-HSV-2 IgG antibody in vaccinated mice and guinea pigs correlates with protection against herpes simplex virus 2.Prospects and perspectives for development of a vaccine against herpes simplex virus infections.A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral ImmunityInhibition of HSV-1 Replication by Gene Editing StrategyHerpes simplex virus 2 (HSV-2) infected cell proteins are among the most dominant antigens of a live-attenuated HSV-2 vaccine.Live attenuated herpes simplex virus 2 glycoprotein E deletion mutant as a vaccine candidate defective in neuronal spread.Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.Future of an "Asymptomatic" T-cell Epitope-Based Therapeutic Herpes Simplex VaccineHSV-2 inhibits type-I interferon signaling via multiple complementary and compensatory STAT2-associated mechanismsThe challenge of developing a herpes simplex virus 2 vaccine.Herpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections.HSV-2 vaccine: current status and insight into factors for developing an efficient vaccine.Histone modifications in herpesvirus infections.Antigenic breadth: a missing ingredient in HSV-2 subunit vaccines?Immunogenic HSV-mediated oncolysis shapes the antitumor immune response and contributes to therapeutic efficacy.A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4+ and CD8+ T Cells.Attenuated Phenotype and Immunogenic Characteristics of a Mutated Herpes Simplex Virus 1 Strain in the Rhesus Macaque.Interaction between the cellular E3 ubiquitin ligase SIAH-1 and the viral immediate-early protein ICP0 enables efficient replication of Herpes Simplex Virus type 2 in vivoClinical management of herpes simplex virus infections: past, present, and future
P2860
Q21089976-1F2E98C5-1B74-4F48-9EDF-4B0103AD6185Q33900347-2E7E0F09-8472-4224-8482-405EC939F75BQ34018897-E086802A-6C26-4B36-B831-6375528933F9Q34350019-02AC95B2-370D-4C8B-8372-B64768C4CBAFQ34431547-7F479869-BA21-4BBB-927E-F2B53FA23ABEQ34520389-EA138D7A-8187-482E-BD81-013C56DE9D12Q34521509-3C10E359-2798-45A0-817A-27C86BB86EB6Q35058245-F820F964-B537-49AC-BC9C-25C6F6BEDC69Q35867958-56FF1CA9-E69C-4574-A006-56076361F7FDQ35869527-E9543BAE-7F82-46F1-95E5-0C839BE42380Q36025675-30649965-F4CB-417D-8004-70EF06D58865Q36098919-588B1F61-009A-4DB2-9C53-7BF41E86AA30Q36671106-2260B872-2537-464B-8CEA-6E45412CEE33Q36824210-D36EBE6A-3511-499F-8E03-E77E41BDAF71Q37611796-4C2C2505-84C6-4359-A7EA-0B5293D94C8AQ37970405-A0BF10D7-5258-426A-9018-03C534842FD2Q38212516-71C82B76-D132-41F0-8518-85BBF204C42AQ38648891-1A19717D-CB65-4CBD-8C49-9EC0600B3E92Q40067153-4F05C040-E6F0-4585-90DB-CDE35109F9F5Q55284064-07EADC40-6447-42C7-A091-8BD4351D7FFAQ57005693-E5AE3C98-BEE8-4388-98E3-0E7152DD72B3Q59133817-DD127C38-14C7-44E7-9168-4B471A8304EC
P2860
Herpes simplex virus 2 ICP0 mutant viruses are avirulent and immunogenic: implications for a genital herpes vaccine
description
2010 nî lūn-bûn
@nan
2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@ast
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@en
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@en-gb
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@nl
type
label
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@ast
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@en
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@en-gb
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@nl
altLabel
Herpes Simplex Virus 2 ICP0− M ...... s for a Genital Herpes Vaccine
@en
prefLabel
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@ast
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@en
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@en-gb
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@nl
P2093
P2860
P3181
P1433
P1476
Herpes simplex virus 2 ICP0 mu ...... s for a genital herpes vaccine
@en
P2093
Brandon Rakowski
Ringo Püschel
William P Halford
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0012251
P407
P577
2010-01-01T00:00:00Z