Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation
about
Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamationIdentification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermisExpression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- miceMatriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndromeProtease and protease-activated receptor-2 signaling in the pathogenesis of atopic dermatitisKLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton SyndromeDown-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissuesBiochemical features, molecular biology and clinical relevance of the human 15-domain serine proteinase inhibitor LEKTISpecificity profiling of seven human tissue kallikreins reveals individual subsite preferencesHuman kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skinSpink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivityHuman tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progressionKallikrein gene downregulation in breast cancer.The kallikrein gene 5 splice variant 2 is a new biomarker for breast and ovarian cancer.Defining the extended substrate specificity of kallikrein 1-related peptidases.Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade.A completed KLK activome profile: investigation of activation profiles of KLK9, 10, and 15The KLK5 protease suppresses breast cancer by repressing the mevalonate pathwayEpidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samplesCloning and characterization of the cDNA and gene for human epitheliasin.Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skinKallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum.Human tissue kallikreins: a new enzymatic cascade pathway?Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesionsGene expression profiling in pachyonychia congenita skinSparse multi-view matrix factorization: a multivariate approach to multiple tissue comparisons.The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers.Stratum corneum defensive functions: an integrated view.Interactions among stratum corneum defensive functions.Recombinant kallikrein expression: site-specific integration for hK6 production in human cells.Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancerTargeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology.Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axisCharacterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.pH-regulated mechanisms account for pigment-type differences in epidermal barrier functionNew insights into the functional mechanisms and clinical applications of the kallikrein-related peptidase family.Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.Predictions for the future of kallikrein-related peptidases in molecular diagnostics.
P2860
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P2860
Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Purification, molecular clonin ...... sible function in desquamation
@ast
Purification, molecular clonin ...... sible function in desquamation
@en
Purification, molecular clonin ...... sible function in desquamation
@en-gb
Purification, molecular clonin ...... sible function in desquamation
@nl
type
label
Purification, molecular clonin ...... sible function in desquamation
@ast
Purification, molecular clonin ...... sible function in desquamation
@en
Purification, molecular clonin ...... sible function in desquamation
@en-gb
Purification, molecular clonin ...... sible function in desquamation
@nl
prefLabel
Purification, molecular clonin ...... sible function in desquamation
@ast
Purification, molecular clonin ...... sible function in desquamation
@en
Purification, molecular clonin ...... sible function in desquamation
@en-gb
Purification, molecular clonin ...... sible function in desquamation
@nl
P2860
P356
P1476
Purification, molecular clonin ...... sible function in desquamation
@en
P2093
M Brattsand
P2860
P304
P356
10.1074/JBC.274.42.30033
P407
P577
1999-10-15T00:00:00Z