Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin - Test2 - elhamkhani - TriplyDB

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

http://www.wikidata.org/entity/Q22061979

about

Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium.Discovery and resupply of pharmacologically active plant-derived natural products: A review Porphyrins as Catalysts in Scalable Organic Reactions The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry Flow "Fine" Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods Recent advances in malaria drug discovery Ten-Minute Protein Purification and Surface Tethering for Continuous-Flow Biocatalysis.Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery.Towards a molecular understanding of the biosynthesis of amaryllidaceae alkaloids in support of their expanding medical use.Schistosomiasis chemotherapy.21st century natural product research and drug development and traditional medicines Differential transcriptome analysis of glandular and filamentous trichomes in Artemisia annua Applying green chemistry to the photochemical route to artemisinin.A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.Scalable synthesis of sequence-defined, unimolecular macromolecules by Flow-IEG.Free Radical Chemistry Enabled by Visible Light-Induced Electron Transfer.Temporal mapping of photochemical reactions and molecular excited states with carbon specificity.Batch and flow photochemical benzannulations based on the reaction of ynamides and diazo ketones. Application to the synthesis of polycyclic aromatic and heteroaromatic compounds.Flow photochemistry: Old light through new windows Industrial natural product chemistry for drug discovery and development.Natural product synthesis in the age of scalability.Potential ecological roles of artemisinin produced by Artemisia annua L.Natural products – learning chemistry from plants.Accessing new chemical entities through microfluidic systems.Photochemical transformations accelerated in continuous-flow reactors: basic concepts and applications.Synthetic chemistry fuels interdisciplinary approaches to the production of artemisinin.The Development of Visible-Light Photoredox Catalysis in Flow.The utilization of copper flow reactors in organic synthesis.Liquid phase oxidation chemistry in continuous-flow microreactors.Artemisinin, a miracle of traditional Chinese medicine.Studies in organic and physical photochemistry - an interdisciplinary approach.Synthetic Strategies for Peroxide Ring Construction in Artemisinin.Unlocking the potential benefits of flow chemistry in the drug-discovery process.Continuous Photo-Oxidation in a Vortex Reactor: Efficient Operations Using Air Drawn from the Laboratory.A flow reactor setup for photochemistry of biphasic gas/liquid reactions.An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde.Optimising Terpene Synthesis with Flow Biocatalysis.Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides.Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine.Natural products in synthesis and biosynthesis.

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Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

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Angewandte Chemie International Edition

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François Lévesque

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P2860

Qinghaosu (Artemisinin): The Price of Success

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Total synthesis of qinghaosu

Physical mechanisms of generation and deactivation of singlet oxygen.

An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb.

The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.

Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis.

Ten key issues in modern flow chemistry.

A practical flow reactor for continuous organic photochemistry.

Highly efficient continuous flow reactions using singlet oxygen as a "green" reagent.

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1706-1709

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scholarly article

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10.1002/ANIE.201107446

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7

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Peter H. Seeberger

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221752135

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