Resolving the ortholog conjecture: orthologs tend to be weakly, but significantly, more similar in function than paralogs
about
Multi-walled carbon nanotube-induced gene expression in vitro: concordance with in vivo studiesDiversity in protein domain superfamiliesComplexity of gene expression evolution after duplication: protein dosage rebalancingA pluralistic account of homology: adapting the models to the dataIs the bovine lysosomal phospholipase B-like protein an amidase?Applications of comparative evolution to human disease geneticsBig data and other challenges in the quest for orthologsAnalysis of 41 plant genomes supports a wave of successful genome duplications in association with the Cretaceous-Paleogene boundaryWORMHOLE: Novel Least Diverged Ortholog Prediction through Machine LearningSTRING v9.1: protein-protein interaction networks, with increased coverage and integrationStandardized benchmarking in the quest for orthologsProtein Function Prediction: Problems and Pitfalls.Phenotype ontologies and cross-species analysis for translational researchThe ortholog conjecture is untestable by the current gene ontology but is supported by RNA sequencing data.Gene family level comparative analysis of gene expression in mammals validates the ortholog conjecture.Global regulatory architecture of human, mouse and rat tissue transcriptomes.Efficient purging of deleterious mutations in plants with haploid selfing.Inter-Protein Sequence Co-Evolution Predicts Known Physical Interactions in Bacterial Ribosomes and the Trp OperonPhyletic profiling with cliques of orthologs is enhanced by signatures of paralogy relationships.The impact of gene duplication, insertion, deletion, lateral gene transfer and sequencing error on orthology inference: a simulation studyIdentification of a novel Gig2 gene family specific to non-amniote vertebrates.Variations within class-A β-lactamase physiochemical properties reflect evolutionary and environmental patterns, but not antibiotic specificityConserved syntenic clusters of protein coding genes are missing in birds.Triticeae resources in Ensembl Plants.Inference of gene-phenotype associations via protein-protein interaction and orthology.Identification of new members of the MAPK gene family in plants shows diverse conserved domains and novel activation loop variants.Quickly finding orthologs as reciprocal best hits with BLAT, LAST, and UBLAST: how much do we miss?A phylogeny-based benchmarking test for orthology inference reveals the limitations of function-based validationA meta-approach for improving the prediction and the functional annotation of ortholog groups.Genome-wide identification of MAPK, MAPKK, and MAPKKK gene families and transcriptional profiling analysis during development and stress response in cucumberProtein homology reveals new targets for bioactive small molecules.Ligand Similarity Complements Sequence, Physical Interaction, and Co-Expression for Gene Function Prediction.Genome-wide identification, phylogeny and expressional profiles of mitogen activated protein kinase kinase kinase (MAPKKK) gene family in bread wheat (Triticum aestivum L.).Tissue-Specificity of Gene Expression Diverges Slowly between Orthologs, and Rapidly between Paralogs.Transport capabilities of environmental Pseudomonads for sulfur compounds.Orthograph: a versatile tool for mapping coding nucleotide sequences to clusters of orthologous genes.OrtholugeDB: a bacterial and archaeal orthology resource for improved comparative genomic analysis.Ensembl comparative genomics resources.Functional Annotations of Paralogs: A Blessing and a CurseGET_HOMOLOGUES, a versatile software package for scalable and robust microbial pangenome analysis.
P2860
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P2860
Resolving the ortholog conjecture: orthologs tend to be weakly, but significantly, more similar in function than paralogs
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2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
Resolving the ortholog conject ...... ilar in function than paralogs
@ast
Resolving the ortholog conject ...... ilar in function than paralogs
@en
Resolving the ortholog conject ...... ilar in function than paralogs
@en-gb
Resolving the ortholog conject ...... ilar in function than paralogs
@nl
type
label
Resolving the ortholog conject ...... ilar in function than paralogs
@ast
Resolving the ortholog conject ...... ilar in function than paralogs
@en
Resolving the ortholog conject ...... ilar in function than paralogs
@en-gb
Resolving the ortholog conject ...... ilar in function than paralogs
@nl
prefLabel
Resolving the ortholog conject ...... ilar in function than paralogs
@ast
Resolving the ortholog conject ...... ilar in function than paralogs
@en
Resolving the ortholog conject ...... ilar in function than paralogs
@en-gb
Resolving the ortholog conject ...... ilar in function than paralogs
@nl
P2860
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Resolving the ortholog conject ...... ilar in function than paralogs
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P2860
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10.1371/JOURNAL.PCBI.1002514
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2012-01-01T00:00:00Z