Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.
about
Epigenetic field defects in progression to cancerA centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage.BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication.p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability.The role of cell density and intratumoral heterogeneity in multidrug resistance.BRCA2 and TP53 collaborate in tumorigenesis in zebrafish.Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance.Chromosome instability and carcinogenesis: insights from murine models of human pancreatic cancer associated with BRCA2 inactivationA subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination.Effects of tumor-associated mutations on Rad54 functions.BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage.BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity.Loss of heterozygosity at BRCA1 locus is significantly associated with aggressiveness and poor prognosis in breast cancer.
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P2860
Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.
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2002 nî lūn-bûn
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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2002 թվականի փետրվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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Disruption of Brca2 increases ...... ergism with ionizing radiation
@nl
Disruption of Brca2 increases ...... rgism with ionizing radiation.
@ast
Disruption of Brca2 increases ...... rgism with ionizing radiation.
@en
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label
Disruption of Brca2 increases ...... ergism with ionizing radiation
@nl
Disruption of Brca2 increases ...... rgism with ionizing radiation.
@ast
Disruption of Brca2 increases ...... rgism with ionizing radiation.
@en
prefLabel
Disruption of Brca2 increases ...... ergism with ionizing radiation
@nl
Disruption of Brca2 increases ...... rgism with ionizing radiation.
@ast
Disruption of Brca2 increases ...... rgism with ionizing radiation.
@en
P2093
P2860
P356
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Disruption of Brca2 increases ...... rgism with ionizing radiation.
@en
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Andrew N J Tutt
Conny Th M van Oostrom
Gillian M Ross
Harry van Steeg
P2860
P304
P356
10.1093/EMBO-REPORTS/KVF037
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P577
2002-02-15T00:00:00Z