Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine
about
The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis ProjectNLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 miceNeuroimmune Interaction in the Regulation of Peripheral Opioid-Mediated Analgesia in InflammationRole of Glia in Stress-Induced Enhancement and Impairment of MemoryRole of pro-inflammatory cytokines released from microglia in Alzheimer's diseaseRodent models of neuroinflammation for Alzheimer's diseaseTurning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease PathogenesisMicroglia development and functionMonoaminergic and Histaminergic Strategies and Treatments in Brain DiseasesUncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD NetworkThe role of orphanin FQ/nociceptin in neuroplasticity: relationship to stress, anxiety and neuroinflammation.Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors.In vivo dynamics of innate immune sentinels in the CNS.Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.Investigating Focal Connectivity Deficits in Alzheimer's Disease Using Directional Brain Networks Derived from Resting-State fMRI.Ear2 deletion causes early memory and learning deficits in APP/PS1 mice.Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performanceMicroglial phenotype and adaptation.PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation.Noradrenergic regulation of glial activation: molecular mechanisms and therapeutic implications.The catecholamine biosynthetic enzyme dopamine β-hydroxylase (DBH): first genome-wide search positions trait-determining variants acting additively in the proximal promoter.CD36 upregulation mediated by intranasal LV-NRF2 treatment mitigates hypoxia-induced progression of Alzheimer's-like pathogenesis.Slowing down: age-related neurobiological predictors of processing speed.Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neuronsInsulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brainsA novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis.Noradrenergic dysfunction in Alzheimer's disease.Age-related neurodegeneration and memory loss in down syndrome.Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease.Noninvasive molecular imaging of neuroinflammationExendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection.The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease.Soluble beta amyloid evokes alteration in brain norepinephrine levels: role of nitric oxide and interleukin-1.Quercitrin for periodontal regeneration: effects on human gingival fibroblasts and mesenchymal stem cells.Norepinephrine Protects against Amyloid-β Toxicity via TrkB.The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain.The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer's diseaseDifferential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease.Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease.Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders
P2860
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P2860
Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@ast
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@en
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@nl
type
label
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@ast
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@en
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@nl
prefLabel
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@ast
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@en
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Locus ceruleus controls Alzhei ...... nctions through norepinephrine
@en
P2093
Ana Martinez-Hernandez
Daniel Jardanhazi-Kurutz
Dick Terwel
Fabian Nadrigny
Jochen Walter
Lucia Dumitrescu-Ozimek
Michael T Heneka
Tommy Regen
P2860
P304
P3181
P356
10.1073/PNAS.0909586107
P407
P577
2010-03-30T00:00:00Z