Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
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Fast, non-competitive and reversible inhibition of NMDA-activated currents by 2-BFI confers neuroprotectionGalanin in Alzheimer's disease: neuroinhibitory or neuroprotective?S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptideMemantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapsesInvestigation on quantitative structure activity relationships and pharmacophore modeling of a series of mGluR2 antagonistsProteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptorMulti-Target Directed Donepezil-Like Ligands for Alzheimer's DiseaseOne for All? Hitting Multiple Alzheimer's Disease Targets with One DrugTowards medication-enhancement of cognitive interventions in schizophreniaThe Role of Hippocampal NMDA Receptors in Long-Term Emotional Responses following Muscarinic Receptor ActivationX-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptorS-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegenerationGinsenoside Rd protects neurons against glutamate-induced excitotoxicity by inhibiting ca(2+) influxThe neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?The chemical biology of clinically tolerated NMDA receptor antagonistsA new target for amyloid beta toxicity validated by standard and high-throughput electrophysiologyCopper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse modelDAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in strokeFrom single target to multitarget/network therapeutics in Alzheimer's therapyPharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular diseaseN-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus InfectionOpportunities to minimise risk in drug discovery and development.Effects of memantine on mitochondrial function.Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)Are we studying and treating schizophrenia correctly?Pharmacodynamics of memantine: an update.The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo.Memantine effects on verbal memory in fragile X-associated tremor/ataxia syndrome (FXTAS): a double-blind brain potential study.Effect of memantine on CBF and CMRO2 in patients with early Parkinson's disease.Neurological implications of urea cycle disordersTreatment of the Ppt1(-/-) mouse model of infantile neuronal ceroid lipofuscinosis with the N-methyl-D-aspartate (NMDA) receptor antagonist memantine.Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease.High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.Serine racemase deletion protects against cerebral ischemia and excitotoxicity.Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts.Homeostatic disinhibition in the aging brain and Alzheimer's diseaseSurvival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylationInfluence of the NR3A subunit on NMDA receptor functions.Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin.
P2860
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P2860
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@ast
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@en
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@en-gb
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@nl
type
label
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@ast
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@en
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@en-gb
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@nl
altLabel
Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond
@en
prefLabel
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@ast
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@en
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@en-gb
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@nl
P3181
P356
P1476
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
@en
P2093
Stuart A. Lipton
P2888
P304
P3181
P356
10.1038/NRD1958
P407
P577
2006-01-20T00:00:00Z
P5875
P6179
1053003644