WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer
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Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress responseShepherding AKT and androgen receptor by Ack1 tyrosine kinaseWWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteinsWW domains provide a platform for the assembly of multiprotein networksWWOX: a candidate tumor suppressor gene involved in multiple tumor typesInhibition of topoisomerase I prevents chromosome breakage at common fragile sitesFunctional association between Wwox tumor suppressor protein and p73, a p53 homologA census of human cancer genesFrequent downregulation and loss of WWOX gene expression in human hepatocellular carcinomaTargeted deletion of Wwox reveals a tumor suppressor functionWWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcomeCommon fragile sites: genomic hotspots of DNA damage and carcinogenesisSETD2: an epigenetic modifier with tumor suppressor functionalityHYAL-2-WWOX-SMAD4 Signaling in Cell Death and Anticancer ResponseWWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancerPleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer CellsWWOX, the common chromosomal fragile site, FRA16D, cancer geneDramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in ratsDrosophila activated Cdc42 kinase has an anti-apoptotic functionThe WWOX tumor suppressor is essential for postnatal survival and normal bone metabolismA genome-wide association study identifies susceptibility variants for type 2 diabetes in Han ChineseThe tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardationGeneration and characterization of mice carrying a conditional allele of the Wwox tumor suppressor geneA novel approach to simultaneously scan genes at fragile sitesWwox-Brca1 interaction: role in DNA repair pathway choiceDNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.Genetics of prostate cancer.Homozygous deletion mapping in myeloma samples identifies genes and an expression signature relevant to pathogenesis and outcomeMolecular alterations in the tumor suppressor gene WWOX in oral leukoplakias.WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.WWOX protein expression in normal human tissues.Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor statusWWOX gene restoration prevents lung cancer growth in vitro and in vivoAssociation between decreased WWOX protein expression and thyroid cancer developmentLow levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours.WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear.Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches.Diverse effect of WWOX overexpression in HT29 and SW480 colon cancer cell lines.WWOX suppresses KLF5 expression and breast cancer cell growth
P2860
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P2860
WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@ast
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@en
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@en-gb
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@nl
type
label
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@ast
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@en
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@en-gb
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@nl
prefLabel
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@ast
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@en
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@en-gb
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@nl
P2093
P3181
P1433
P1476
WWOX, a novel WW domain-contai ...... ntly affected in breast cancer
@en
P2093
P304
P3181
P407
P577
2000-04-15T00:00:00Z