A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease
about
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondriaGenes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouseKinetic and structural characterization of an alternatively spliced variant of human mitochondrial 5'(3')-deoxyribonucleotidaseHuman mitochondrial 5'-deoxyribonucleotidase. Overproduction in cultured cells and functional aspectsGene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediatorsEnzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replicationPenetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alikeBovine cytosolic 5'-nucleotidase acts through the formation of an aspartate 52-phosphoenzyme intermediate.Inherited mitochondrial DNA depletion.Hepatitis C virus non-structural protein 3 interacts with cytosolic 5'(3')-deoxyribonucleotidase and partially inhibits its activity.Heart mitochondrial TTP synthesis and the compartmentalization of TMP.Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiencyRole of IMP-selective 5'-nucleotidase (cN-II) in hematological malignancies.The role of nucleoside/nucleotide transport and metabolism in the uptake and retention of 3'-fluoro-3'-deoxythymidine in human B-lymphoblast cells.YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12Origins of mitochondrial thymidine triphosphate: dynamic relations to cytosolic pools.Hereditary pyrimidine 5'-nucleotidase deficiency: from genetics to clinical manifestations.Ribonucleotide reductase association with mammalian liver mitochondria.Determination of the enzymatic activity of cytosolic 5'-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models.Mitochondrial deoxyribonucleotides, pool sizes, synthesis, and regulation.Cytosolic high K(m) 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism.Chicken erythrocyte pyrimidine 5'-nucleotidase: purification and characterization of the subclass I enzyme.Identification of the 5'-nucleotidase activity altered in neurological syndromes.TMP; (d)UMP; uridine 2' monophosphate; or uridine 3'-monophosphate + H2O => thymidine; deoxyuridine; or uridine + orthophosphateMammalian 5'-nucleotidases.
P2860
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P2860
A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@ast
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@en
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@en-gb
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@nl
type
label
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@ast
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@en
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@en-gb
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@nl
prefLabel
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@ast
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@en
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@en-gb
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@nl
P2093
P2860
P921
P356
P1476
A deoxyribonucleotidase in mit ...... ssible link to genetic disease
@en
P2093
C Rampazzo
E Frigimelica
E Milanesi
L Gallinaro
P Reichard
P2860
P304
P356
10.1073/PNAS.97.15.8239
P407
P577
2000-07-18T00:00:00Z