Covariation of human microsomal protein per gram of liver with age: absence of influence of operator and sample storage may justify interlaboratory data pooling
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Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric populationDevelopment of a physiologically based model to describe the pharmacokinetics of methylphenidate in juvenile and adult humans and nonhuman primatesA re-evaluation and validation of ontogeny functions for cytochrome P450 1A2 and 3A4 based on in vivo data.Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic ClearanceApplication of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.The development of UDP-glucuronosyltransferases 1A1 and 1A6 in the pediatric liverThe role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development.Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV.Neonatal development of hepatic UGT1A9: implications of pediatric pharmacokinetics.Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo.Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content.Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis.A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporinePhysiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology.Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability.Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions with Efavirenz Involving Simultaneous Inducing and Inhibitory Effects on Cytochromes.Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors.Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling.A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer.Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study.Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.The Effects of Aging on Hepatic Microsomal Scaling Factor and Hepatocellularity Number in the Horse.Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model.Microsomal protein per gram of liver (MPPGL) in paediatric biliary atresia patients.Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model II: Verification of the model for passive placental permeability drugs.The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM).Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding.In silico (computed) modelling of doses and dosing regimens associated with morphine levels above international legal driving limits.An Accelerator Mass Spectrometry-Enabled Microtracer Study to Evaluate the First-Pass Effect on the Absorption of YH4808.The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research.
P2860
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P2860
Covariation of human microsomal protein per gram of liver with age: absence of influence of operator and sample storage may justify interlaboratory data pooling
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Covariation of Human Microsoma ...... y Interlaboratory Data Pooling
@nl
Covariation of human microsoma ...... y interlaboratory data pooling
@ast
Covariation of human microsoma ...... y interlaboratory data pooling
@en
Covariation of human microsoma ...... y interlaboratory data pooling
@en-gb
type
label
Covariation of Human Microsoma ...... y Interlaboratory Data Pooling
@nl
Covariation of human microsoma ...... y interlaboratory data pooling
@ast
Covariation of human microsoma ...... y interlaboratory data pooling
@en
Covariation of human microsoma ...... y interlaboratory data pooling
@en-gb
prefLabel
Covariation of Human Microsoma ...... y Interlaboratory Data Pooling
@nl
Covariation of human microsoma ...... y interlaboratory data pooling
@ast
Covariation of human microsoma ...... y interlaboratory data pooling
@en
Covariation of human microsoma ...... y interlaboratory data pooling
@en-gb
P2093
P921
P3181
P356
P1476
Covariation of human microsoma ...... y interlaboratory data pooling
@en
P2093
A. Rostami-Hodjegan
J. C. Lipscomb
J. E. Chowdry
J. R. Harlow
Z. E. Barter
P2880
P304
P3181
P356
10.1124/DMD.108.021311
P407
P577
2008-09-10T00:00:00Z