Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies - Test2 - elhamkhani - TriplyDB

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

http://www.wikidata.org/entity/Q24289320

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WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength Polymorphisms in the 5' flank of COL1A1 gene and osteoporosis: meta-analysis of published studies Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution Bone composition: relationship to bone fragility and antiosteoporotic drug effects Endocrine crosstalk between muscle and bone A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway Genome-wide association reveals QTL for growth, bone and in vivo carcass traits as assessed by computed tomography in Scottish Blackface lambs.Wnt signaling in bone and muscle WNT signaling in bone homeostasis and disease: from human mutations to treatments Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired Osteogenesis Evidence for pleiotropic factors in genetics of the musculoskeletal system Assessment of gene-by-sex interaction effect on bone mineral density Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging European bone mineral density loci are also associated with BMD in East-Asian populations A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.Using GWAS to identify novel therapeutic targets for osteoporosis.Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.Quantitative trait loci for bone mineral density and femoral morphology in an advanced intercross population of mice Trps1 differentially modulates the bone mineral density between male and female mice and its polymorphism associates with BMD differently between women and men.Systems genetics: a novel approach to dissect the genetic basis of osteoporosis.Future of osteoporosis genetics: enhancing genome-wide association studies Identification of quantitative trait loci influencing skeletal architecture in mice: emergence of Cdh11 as a primary candidate gene regulating femoral morphology An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.Identification of a gene module associated with BMD through the integration of network analysis and genome-wide association data.A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study.Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?Fast linear mixed model computations for genome-wide association studies with longitudinal data.Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium Discovery of phenotypic networks from genotypic association studies with application to obesity.

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Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

http://www.wikidata.org/entity/Q24289320

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2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Ben Oostra

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Fotini K Kavvoura

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Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study.

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Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations

Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells

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10.1038/NG.446

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